Background Severe burn is a systemic illness often complicated by sepsis. Kidney is one of
the organs invariably affected, and proteinuria is a constant clinical finding. We studied the …

Purpose The histopathology of sepsis-associated acute kidney injury (AKI) in critically ill
patients remains an understudied area. Previous studies have identified that acute tubular …

Background Acute lung injury (ALI) is a major cause of acute respiratory failure with high
mortality despite lung-protective ventilation. Prior work has shown disordered inflammation …

Background Early survival following severe injury has been improved with refined
resuscitation strategies. Multiple organ dysfunction syndrome (MODS) is common among …

Background Renal perfusion status remains poorly studied at the bedside during septic
shock. We sought to measure cortical renal perfusion in patients with septic shock during …

Background A dysbalanced coagulation system is part of the pathological host response to
infection in sepsis. Activation of pro-coagulant pathways and attenuation of anti-coagulant …

Introduction Cytokines are believed to play an important role in acute-on-chronic liver failure
(ACLF). Extracorporeal liver support systems may exert beneficial effects in ACLF via …

Introduction Septic renal failure is often seen in the intensive care unit but its pathogenesis is
only partly understood. This study, performed in a normotensive rat model of endotoxemia …

Introduction Acute kidney injury (AKI) is a common and feared complication of sepsis. The
pathogenesis of sepsis-induced AKI is largely unknown, and therapeutic interventions are …

Introduction Hemofiltration may modulate the inflammatory response in sepsis through a
variety of mechanisms. We sought to distinguish clearance from adsorption as the principal …