Depression has emerged as a major cause of mortality globally. Many studies have reported
risk factors and mechanisms associated with depression, but it is as yet unclear how these …

Depression is a highly prevalent mood disorder and one of the major health concerns in
modern society. Moreover, it is characterized by a high prevalence of coexistence with many …

Background Both depression itself and antidepressant medication have been reported to be
significantly related to the risk of type 2 diabetes mellitus (T2DM). Glucagon-like peptide-1 …

Diabetes mellitus is one of the major risk factors for cognitive dysfunction. The pathogenesis
of brain impairment caused by chronic hyperglycemia is complex and includes …

Abstract Glucagon-like peptide 1 (GLP-1), produced in the intestine and hindbrain, is known
for its glucoregulatory and appetite suppressing effects. GLP-1 agonists are in clinical use …

The glucagon-like peptide-1 (GLP-1) is a pleiotropic hormone well known for its incretin
effect in the glucose-dependent stimulation of insulin secretion. However, GLP-1 is also …

Chronic, excessive neuroinflammation is a key feature of neurodegenerative diseases such
as Alzheimer's disease (AD) and Parkinson's disease (PD). However, neuroinflammatory …

Alzheimer's disease (AD), characterized by the aggregation of amyloid-β (Aβ) protein and
neuroinflammation, is the most common neurodegenerative disease globally. Previous …

Stress and low mood are powerful triggers for compulsive overeating, a maladaptive form of
eating leading to negative physical and mental health consequences. Stress-vulnerable …

Glucagon-like peptide-1 (GLP-1) is released in response to meals and exerts important roles
in the maintenance of normal glucose homeostasis. GLP-1 is also important in the regulation …