The Warburg effect then and now: from cancer to inflammatory diseases
EM Palsson‐McDermott, LA O'neill - Bioessays, 2013 - Wiley Online Library
Inflammatory immune cells, when activated, display much the same metabolic profile as a
glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation …
glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation …
The immunologic Warburg effect: Evidence and therapeutic opportunities in autoimmunity
MD Kornberg - Wiley Interdisciplinary Reviews: Systems …, 2020 - Wiley Online Library
Pro‐inflammatory signals induce metabolic reprogramming in innate and adaptive immune
cells of both myeloid and lymphoid lineage, characterized by a shift to aerobic glycolysis …
cells of both myeloid and lymphoid lineage, characterized by a shift to aerobic glycolysis …
The Warburg effect: insights from the past decade
Several decades ago, Otto Warburg discovered that cancer cells produce energy
predominantly by glycolysis; a phenomenon now termed “Warburg effect”. Warburg linked …
predominantly by glycolysis; a phenomenon now termed “Warburg effect”. Warburg linked …
[HTML][HTML] Biochemistry of proinflammatory macrophage activation
Y Nonnenmacher, K Hiller - Cellular and molecular life sciences, 2018 - Springer
In the last decade, metabolism has been recognized as a major determinant of
immunological processes. During an inflammatory response, macrophages undergo striking …
immunological processes. During an inflammatory response, macrophages undergo striking …
[HTML][HTML] Fatty acid oxidation compensates for lipopolysaccharide-induced Warburg effect in glucose-deprived monocytes
N Raulien, K Friedrich, S Strobel, S Rubner… - Frontiers in …, 2017 - frontiersin.org
Monocytes enter sites of microbial or sterile inflammation as the first line of defense of the
immune system and initiate pro-inflammatory effector mechanisms. We show that activation …
immune system and initiate pro-inflammatory effector mechanisms. We show that activation …
The Warburg effect: evolving interpretations of an established concept
Metabolic reprogramming and altered bioenergetics have emerged as hallmarks of cancer
and an area of active basic and translational cancer research. Drastically upregulated …
and an area of active basic and translational cancer research. Drastically upregulated …
The interplay between central metabolism and innate immune responses
A growing body of recent studies bring into light an important cross-talk between immune
response and metabolism not only at the level of the organism as a whole, but also at the …
response and metabolism not only at the level of the organism as a whole, but also at the …
[HTML][HTML] Cancer cell metabolism: Warburg and beyond
PP Hsu, DM Sabatini - Cell, 2008 - cell.com
Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark
of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg …
of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg …
[HTML][HTML] Metabolic reprogramming in macrophages and dendritic cells in innate immunity
B Kelly, LA O'neill - Cell research, 2015 - nature.com
Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes
them to undergo a metabolic switch towards glycolysis and away from oxidative …
them to undergo a metabolic switch towards glycolysis and away from oxidative …
Metabolic reprogramming of host cells upon bacterial infection: Why shift to a Warburg‐like metabolism?
P Escoll, C Buchrieser - The FEBS journal, 2018 - Wiley Online Library
The finding that the Warburg effect observed in proliferating cancer cells is also observed
during immune responses renewed the interest in the study of metabolic reprogramming of …
during immune responses renewed the interest in the study of metabolic reprogramming of …