Inflammatory immune cells, when activated, display much the same metabolic profile as a
glycolytic tumor cell. This involves a shift in metabolism away from oxidative phosphorylation …

Pro‐inflammatory signals induce metabolic reprogramming in innate and adaptive immune
cells of both myeloid and lymphoid lineage, characterized by a shift to aerobic glycolysis …

Several decades ago, Otto Warburg discovered that cancer cells produce energy
predominantly by glycolysis; a phenomenon now termed “Warburg effect”. Warburg linked …

In the last decade, metabolism has been recognized as a major determinant of
immunological processes. During an inflammatory response, macrophages undergo striking …

Monocytes enter sites of microbial or sterile inflammation as the first line of defense of the
immune system and initiate pro-inflammatory effector mechanisms. We show that activation …

Metabolic reprogramming and altered bioenergetics have emerged as hallmarks of cancer
and an area of active basic and translational cancer research. Drastically upregulated …

A growing body of recent studies bring into light an important cross-talk between immune
response and metabolism not only at the level of the organism as a whole, but also at the …

Described decades ago, the Warburg effect of aerobic glycolysis is a key metabolic hallmark
of cancer, yet its significance remains unclear. In this Essay, we re-examine the Warburg …

Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes
them to undergo a metabolic switch towards glycolysis and away from oxidative …

The finding that the Warburg effect observed in proliferating cancer cells is also observed
during immune responses renewed the interest in the study of metabolic reprogramming of …