Cerebral Malaria and Neuronal Implications of Plasmodium Falciparum Infection: From Mechanisms to Advanced Models

OB Akide Ndunge, N Kilian, MM Salman - Advanced Science, 2022 - Wiley Online Library
Reorganization of host red blood cells by the malaria parasite Plasmodium falciparum
enables their sequestration via attachment to the microvasculature. This artificially increases …

Cerebral malaria: mysteries at the blood-brain barrier

L Rénia, SW Howland, C Claser, AC Gruner… - Virulence, 2012 - Taylor & Francis
Cerebral malaria is the most severe pathology caused by the malaria parasite, Plasmodium
falciparum. The pathogenic mechanisms leading to cerebral malaria are still poorly defined …

Human cerebral malaria and the blood–brain barrier

IM Medana, GDH Turner - International journal for parasitology, 2006 - Elsevier
Malaria represents a continuing and major global health challenge and our understanding
of how the Plasmodium parasite causes severe disease and death remains poor. One …

Breaking down the blood–brain barrier: signaling a path to cerebral malaria?

S Adams, H Brown, G Turner - Trends in parasitology, 2002 - cell.com
Cerebral malaria is a major killer in the developing world, but we still know very little about
the causes of this disease. How does Plasmodium falciparum cause such a devastating …

Severe malaria: what's new on the pathogenesis front?

SC Wassmer, GER Grau - International journal for parasitology, 2017 - Elsevier
Plasmodium falciparum causes the most severe and fatal form of malaria in humans with
over half a million deaths each year. Cerebral malaria, a complex neurological syndrome of …

Binding heterogeneity of Plasmodium falciparum to engineered 3D brain microvessels is mediated by EPCR and ICAM-1

M Bernabeu, C Gunnarsson, M Vishnyakova… - MBio, 2019 - Am Soc Microbiol
Cerebral malaria is a severe neurological complication associated with sequestration of
Plasmodium falciparum-infected erythrocytes (IE) in the brain microvasculature, but the …

Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood–brain barrier in cerebral malaria

Y Adams, RW Olsen, A Bengtsson… - Journal of Experimental …, 2021 - rupress.org
Cerebral malaria (CM) is caused by the binding of Plasmodium falciparum–infected
erythrocytes (IEs) to the brain microvasculature, leading to inflammation, vessel occlusion …

Cerebral malaria – modelling interactions at the blood–brain barrier in vitro

Y Adams, AR Jensen - Disease Models & Mechanisms, 2022 - journals.biologists.com
The blood–brain barrier (BBB) is a continuous endothelial barrier that is supported by
pericytes and astrocytes and regulates the passage of solutes between the bloodstream and …

[HTML][HTML] Neurological complications of malaria

S Trivedi, A Chakravarty - Current neurology and neuroscience reports, 2022 - Springer
Abstract Purpose of Review To discuss the neurological complications and pathophysiology
of organ damage following malaria infection. Recent Findings The principal advancement …

Blood–brain barrier in falciparum malaria

EN Gitau, C Newton - Tropical Medicine & International Health, 2005 - Wiley Online Library
Plasmodium falciparum malaria is the most important parasitic disease infecting the central
nervous system of humans worldwide. The pathogenesis of the neurological complications …