Among many methods to mitigate the solubility limitations of drug compounds, amorphous
solid dispersion (ASD) is considered to be one of the most promising strategies to enhance …

ABSTRACT Introduction: Amorphous solid dispersions (ASDs) are one of the key
formulation technologies that aid the development of poorly soluble candidates. However …

Amorphous solid dispersion (ASD) technology is an attractive formulation approach for
poorly soluble drugs because of the supersaturated state acquired during its dissolution …

The solubility of a drug is ultimately governed by its chemical potential as it is present in the
undissolved solute. For a pharmaceutical amorphous solid dispersion (ASD), its solubility …

Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble
drugs. However, their use in drug development is comparably rare due to a lack of basic …

Amorphous solid dispersion (ASD) is a promising strategy to enhance solubility and
bioavailability of poorly water-soluble drugs. Due to higher free energy of ASD …

Enzalutamide is a fast crystallizing, hydrophobic compound that has solubility limited
absorption in vivo. Given the low aqueous solubility of this compound, it was of interest to …

The maximum achievable concentration of a drug in solution is dictated by the chemical
potential of the solid form. Because an amorphous solid has a higher chemical potential …

An ideal dissolution test for amorphous solid dispersions (ASDs) should reflect
physicochemical, physiological, and hydrodynamic conditions which accurately represent in …

The objective of the current study is to mechanistically differentiate the dissolution and
supersaturation behaviors of amorphous drugs from amorphous solid dispersions (ASDs) …