Aging is a major risk factor contributing to pathophysiological changes in the heart, yet its
intrinsic mechanisms have been largely unexplored in primates. In this study, we …

Sirtuins have been shown to regulate the aging process. We have previously demonstrated
that Sirt6 blocks the pressure overload-induced cardiac hypertrophy in mice. Here, we show …

The prevalence of heart diseases, such as coronary artery disease and congestive heart
failure, increases with age. Optimal therapeutic interventions that antagonize aging may …

Silent information regulator (Sir) 2, a class III histone deacetylase, mediates lifespan
extension in model organisms and prevents apoptosis in mammalian cells. However …

Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

Background: Pathological cardiac hypertrophy induced by stresses such as aging and
neurohumoral activation is an independent risk factor for heart failure and is considered a …

Cardiovascular disease (CVD) is the leading cause of death worldwide, with aging as the
key independent risk factor. Effective interventions are necessary to delay aging. Sirtuin1 …

Cardiovascular disease is the second leading cause of death (9.1%) in Taiwan. Heart
function deteriorates with age at a rate of 1% per year. As society ages, we must study the …

SIRT6 belongs to the nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases
and has established diverse roles in aging, metabolism and disease. Its function is similar to …

Despite recent controversy about their function in some organisms, sirtuins are thought to
play evolutionarily conserved roles in lifespan extension. Whether sirtuins can reverse aging …