Barriers and strategies to achieve a cure for HIV
9 years since the report of a cure for HIV after CC chemokine receptor type 5 Δ32 stem cell
transplantation, no other case of HIV cure has been reported, despite much research …
transplantation, no other case of HIV cure has been reported, despite much research …
Challenges in detecting HIV persistence during potentially curative interventions: a study of the Berlin patient
There is intense interest in developing curative interventions for HIV. How such a cure will
be quantified and defined is not known. We applied a series of measurements of HIV …
be quantified and defined is not known. We applied a series of measurements of HIV …
Can research at the end of life be a useful tool to advance HIV cure?
S Gianella, J Taylor, TR Brown, A Kaytes, CL Achim… - Aids, 2017 - journals.lww.com
Modern antiretroviral therapy (ART) has saved millions of years of life [1], but it cannot
eradicate latently infected cells [2, 3]. The replication-competent provirus that remains during …
eradicate latently infected cells [2, 3]. The replication-competent provirus that remains during …
HIV cure and eradication: how will we get from the laboratory to effective clinical trials?
SR Lewin, C Rouzioux - Aids, 2011 - journals.lww.com
Combination antiretroviral therapy (cART) has led to a major reduction in HIV-related
mortality and morbidity; however, HIV can still not be cured. Achieving either a functional …
mortality and morbidity; however, HIV can still not be cured. Achieving either a functional …
In-depth virological and immunological characterization of HIV-1 cure after CCR5Δ32/Δ32 allogeneic hematopoietic stem cell transplantation
BEO Jensen, E Knops, L Cords, N Lübke, M Salgado… - Nature medicine, 2023 - nature.com
Despite scientific evidence originating from two patients published to date that
CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human …
CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human …
Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report
Summary Background The London patient (participant 36 in the IciStem cohort) underwent
allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5Δ32/Δ32); …
allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5Δ32/Δ32); …
Barriers to a cure for HIV: new ways to target and eradicate HIV-1 reservoirs
C Katlama, SG Deeks, B Autran, J Martinez-Picado… - The Lancet, 2013 - thelancet.com
Antiretroviral therapy for HIV infection needs lifelong access and strict adherence to
regimens that are both expensive and associated with toxic effects. A curative intervention …
regimens that are both expensive and associated with toxic effects. A curative intervention …
HIV reservoirs as obstacles and opportunities for an HIV cure
The persistence of HIV reservoirs remains a formidable obstacle to achieving sustained
virologic remission in HIV-infected individuals after antiretroviral therapy (ART) is …
virologic remission in HIV-infected individuals after antiretroviral therapy (ART) is …
HIV-1 functional cure: will the dream come true?
C Liu, X Ma, B Liu, C Chen, H Zhang - BMC medicine, 2015 - Springer
The reservoir of human immunodeficiency virus type 1 (HIV-1), a long-lived pool of latently
infected cells harboring replication-competent viruses, is the major obstacle to curing …
infected cells harboring replication-competent viruses, is the major obstacle to curing …
Eradication of HIV from the brain: reasons for pause
A Nath, JE Clements - Aids, 2011 - journals.lww.com
Eradication of HIV was unthinkable a few years ago, but now with a better understanding of
the T-cell reservoirs and the development of new strategies that activate the virus but not …
the T-cell reservoirs and the development of new strategies that activate the virus but not …