Objective Acute kidney injury (AKI) is a common complication of acute liver failure (ALF).
Pyroptosis is a necrosis type related to inflammation. This study aimed to investigate the role …

Extracellular vesicles (EVs) have emerged as important vectors of intercellular dialogue.
High mobility group box protein 1 (HMGB1) is a typical damage-associated molecular …

Background & Aims Liver injury is a common complication of heat stroke (HS), and often
constitutes a direct cause for patient death. The cellular and molecular mechanism …

Gasdermin D (GSDMD), a genetic substrate for inflammatory caspases, plays a central role
in pyroptosis of macrophages and release of interleukin‑1β (IL-1β), but was mainly referred …

Pyroptosis is a programmed cell death associated with caspase-1 and accompanied by the
secretion of a large number of pro-inflammatory cytokines. In the acute stage of sepsis, the …

Renal tubular cell (RTC) death and inflammation contribute to the progression of obstructive
nephropathy, but its underlying mechanisms have not been fully elucidated. Here, we …

The present study aimed to investigate the anti‑ferroptosis effects of the HMGB1 inhibitor
glycyrrhizin (GLY). The present study used a cell and animal model of acute liver failure …

Background. Hepatic ischemia‐reperfusion (I/R) injury is a pivotal clinical problem occurring
in many clinical conditions such as transplantation, trauma, and hepatic failure after …

Pyroptosis is a new necrosis pattern of hepatocyte during liver inflammation in acute liver
failure (ALF). Histone deacetylase 2 (HDAC2) is associated with several pathological …

Pyroptosis is known as a novel form of pro-inflammatory cell death program, which is
exceptional from other types of cell death programs. Particularly, pyroptosis is characterized …