NPM1-mutated acute myeloid leukemia: recent developments and open questions
SS Patel - Pathobiology, 2023 - karger.com
Somatic mutations in the nucleophosmin (NPM1) gene occur in approximately 30% of de
novo acute myeloid leukemias (AMLs) and are relatively enriched in normal karyotype …
novo acute myeloid leukemias (AMLs) and are relatively enriched in normal karyotype …
Molecular heterogeneity and measurable residual disease of rare NPM1 mutations in acute myeloid leukemia: a nationwide experience from the GBMHM study group
E Fournier, M Heiblig, C Lespinasse, P Flandrin-Gresta… - Leukemia, 2022 - nature.com
Nucleophosmin (NPM1)-mutated acute myeloid leukemia (AML) is a recognized entity
related to distinctive biological, clinical, and prognostic features. Nearly all NPM1 variants …
related to distinctive biological, clinical, and prognostic features. Nearly all NPM1 variants …
Minimal residual disease levels assessed by NPM1 mutation–specific RQ-PCR provide important prognostic information in AML
S Schnittger, W Kern, C Tschulik… - Blood, The Journal …, 2009 - ashpublications.org
Abstract Nucleophosmin (NPM1)–mutated acute myeloid leukemia (AML), which is
recognized as a provisional entity in the World Health Organization 2008 classification of …
recognized as a provisional entity in the World Health Organization 2008 classification of …
How I diagnose and treat NPM1-mutated AML
B Falini, L Brunetti, MP Martelli - Blood, The Journal of the …, 2021 - ashpublications.org
Mutations of the nucleophosmin (NPM1) gene, encoding for a nucleolar multifunctional
protein, occur in approximately one-third of adult acute myeloid leukemia (AML). NPM1 …
protein, occur in approximately one-third of adult acute myeloid leukemia (AML). NPM1 …
Clinical outcomes associated with NPM1 mutations in patients with relapsed or refractory AML
GC Issa, A Bidikian, S Venugopal… - Blood …, 2023 - ashpublications.org
Abstract Mutations in Nucleophosmin 1 (NPM1) are associated with a favorable prognosis in
newly diagnosed acute myeloid leukemia (AML), however, their prognostic impact in …
newly diagnosed acute myeloid leukemia (AML), however, their prognostic impact in …
Diagnostic utility of immunohistochemistry in detection of NPM1 mutations in acute myeloid leukemia with a patchy distribution
Q Wei, SA Wang, S Loghavi, H Fang, LJ Medeiros… - Ejhaem, 2024 - Wiley Online Library
Abstract Nucleophosmin 1 (NPM1) mutations occur in approximately one‐third cases of
adult de novo acute myeloid leukemia (AML). Identification of NPM1 mutations is important …
adult de novo acute myeloid leukemia (AML). Identification of NPM1 mutations is important …
[HTML][HTML] Genetic, Phenotypic, and Clinical Heterogeneity of NPM1-Mutant Acute Myeloid Leukemias
U Testa, E Pelosi, G Castelli - Biomedicines, 2023 - mdpi.com
The current classification of acute myeloid leukemia (AML) relies largely on genomic
alterations. AML with mutated nucleophosmin 1 (NPM1-mut) is the largest of the genetically …
alterations. AML with mutated nucleophosmin 1 (NPM1-mut) is the largest of the genetically …
Coexisting and cooperating mutations in NPM1-mutated acute myeloid leukemia
JL Patel, JA Schumacher, K Frizzell, S Sorrells… - Leukemia research, 2017 - Elsevier
NPM1 insertion mutations represent a common recurrent genetic abnormality in acute
myeloid leukemia (AML) patients. The frequency of these mutations varies from …
myeloid leukemia (AML) patients. The frequency of these mutations varies from …
Monitoring of minimal residual disease in acute myeloid leukemia with frequent and rare patient‐specific NPM1 mutations
D Dvorakova, Z Racil, I Jeziskova… - American journal of …, 2010 - Wiley Online Library
Nucleophosmin (NPM1) mutations in exon 12 are the most common genetic alternation in
cytogenetically normal AML (CN‐AML). Although mutation types A, B, and D represent the …
cytogenetically normal AML (CN‐AML). Although mutation types A, B, and D represent the …
[HTML][HTML] NPM1 exon 5 mutations in acute myeloid leukemia: Implications in diagnosis and minimal residual monitoring
P Wang, J Segal, MW Drazer, G Venkataraman… - EJHaem, 2022 - ncbi.nlm.nih.gov
Nucleophosmin 1 (NPM1) mutated acute myeloid leukemia is recognized as distinct entity in
the 2016 revision of the WHO classification [1]. In patients with normal karyotype, presence …
the 2016 revision of the WHO classification [1]. In patients with normal karyotype, presence …