Ungefähr 40% aller potenziellen Wirkstoffkandidaten für den Menschen werden auf Grund
von Leberschäden verworfen. Dies geschieht häufig erst zu einem späten Zeitpunkt in der …

The human vasculature is essential in organs and tissues for the transport of nutrients,
metabolic waste products, and the maintenance of homeostasis. The integration of vessels …

Improving the biological relevance of organs-on-chips is one of the main issues in
biomedical engineering. The microvascular system is related to numerous biological …

The development of long‐term human organotypic liver‐on‐a‐chip models for successful
prediction of toxic response is one of the most important and urgent goals of the …

Zusammenfassung Im Rahmen der Entwicklung und Zulassung potenzieller therapeutischer
Wirkstoffe sind umfangreiche präklinische Untersuchungen und Validierungen erforderlich …

Organ-on-a-chip Systeme sind funktionale, artifizielle Gewebemodelle, welche unter
anderem zur Evaluierung von Wirkstoffen und Therapeutika verwendet werden. Durch den …

To date, tissue engineering and organ‐on‐a‐chip devices become more powerful as
replacements for animal testings in high throughput drug screenings. However, the majority …

Although the process of drug development requires efficacy and toxicity testing in animals
prior to human testing, animal models have limited ability to accurately predict human …

The liver is the most important metabolic hub of endo and xenobiotic compounds. Pre-
clinical studies using rodents to evaluate the toxicity of new drugs and cosmetics may …

A challenge in developing effective treatments is the modeling of the human disease using
in vitro and in vivo systems. Animal models have played a critical role in the understanding …