The activation of Akt/PKB signaling pathway and cell survival

G Song, G Ouyang, S Bao - Journal of cellular and molecular …, 2005 - Wiley Online Library
Akt/PKB is a serine/threonine protein kinase that functions as a critical regulator of cell
survival and proliferation. Akt/PKB family comprises three highly homologous members …

The protein kinase B/Akt signalling pathway in human malignancy

KM Nicholson, NG Anderson - Cellular signalling, 2002 - Elsevier
Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises
three highly homologous members known as PKBα (Akt1), PKBβ (Akt2), and PKBγ (Akt3) …

Involvement of the Akt/PKB signaling pathway with disease processes

P Sen, S Mukherjee, D Ray, S Raha - Molecular and cellular biochemistry, 2003 - Springer
Akt/PKB is a serine/threonine kinase, which controls vital cellular functions such as cell
survival/apoptosis, cell cycle progression and glucose metabolism. Akt/PKB acts down …

The Akt/PKB pathway: molecular target for cancer drug discovery

JQ Cheng, CW Lindsley, GZ Cheng, H Yang… - Oncogene, 2005 - nature.com
The serine/threonine kinase Akt/PKB pathway presents an exciting new target for molecular
therapeutics, as it functions as a cardinal nodal point for transducing extracellular (growth …

AKT signaling in normal and malignant cells

JR Testa, PN Tsichlis - Oncogene, 2005 - nature.com
Abstract AKT/protein kinase B (PKB) is a cardinal node in diverse signaling cascades
important in both normal cellular physiology and various disease states. AKT signaling …

[HTML][HTML] Unravelling the activation mechanisms of protein kinase B/Akt

MP Scheid, JR Woodgett - FEBS letters, 2003 - Elsevier
Over the past decade, protein kinase B (PKB, also termed Akt) has emerged as an important
signaling mediator between extracellular cues and modulation of gene expression …

[HTML][HTML] Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation

L Xiao, LL Gong, D Yuan, M Deng, XM Zeng… - Cell Death & …, 2010 - nature.com
AKT pathway has a critical role in mediating signaling transductions for cell proliferation,
differentiation and survival. Previous studies have shown that AKT activation is achieved …

Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery

LH Wang, GZ Cheng, S Park, S Shu… - Current cancer drug …, 2008 - ingentaconnect.com
AKT (also known as PKB) plays a central role in a variety of cellular processes including cell
growth, motility and survival in both normal and tumor cells. The AKT pathway is also …

Structure, regulation and function of PKB/AKT—a major therapeutic target

M Hanada, J Feng, BA Hemmings - … et Biophysica Acta (BBA)-Proteins and …, 2004 - Elsevier
Protein phosphorylation and dephosphorylation play a major role in intracellular signal
transduction activated by extracellular stimuli. Protein kinase B (PKB/Akt) is a central player …

PI3K/Akt: getting it right matters

TF Franke - Oncogene, 2008 - nature.com
The Akt serine/threonine kinase (also called protein kinase B) has emerged as a critical
signaling molecule within eukaryotic cells. Significant progress has been made in clarifying …