Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy

R Maji, NS Dey, BS Satapathy… - International journal …, 2014 - Taylor & Francis
Background Four formulations of Tamoxifen citrate loaded polylactide-co-glycolide (PLGA)
based nanoparticles (TNPs) were developed and characterized. Their internalization by …

Biodegradable poly (ε-caprolactone) nanoparticles for tumor-targeted delivery of tamoxifen

JS Chawla, MM Amiji - International journal of pharmaceutics, 2002 - Elsevier
To increase the local concentration of tamoxifen in estrogen receptor (ER) positive breast
cancer, we have developed and characterized nanoparticle formulation using poly (ε …

Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: a …

B Sahana, K Santra, S Basu… - International journal of …, 2010 - Taylor & Francis
The aim of the present study was to develop nanoparticles of tamoxifen citrate, a non-
steroidal antiestrogenic drug used for the treatment of breast cancer. Biodegradable poly (D …

The effect of the oral administration of polymeric nanoparticles on the efficacy and toxicity of tamoxifen

AK Jain, NK Swarnakar, C Godugu, RP Singh, S Jain - Biomaterials, 2011 - Elsevier
The present investigation reports on the conditions for preparation of tamoxifen loaded
PLGA nanoparticles (Tmx-NPs) for oral administration. Tmx-NPs with> 85% entrapment …

Tamoxifen-loaded poly (L-lactide) nanoparticles: development, characterization and in vitro evaluation of cytotoxicity

C Altmeyer, TK Karam, NM Khalil… - Materials Science and …, 2016 - Elsevier
In this study, poly (L-lactide)(PLA) nanoparticles containing Tamoxifen (Tmx) were
developed using an emulsion/solvent evaporation method, observing the influence of …

Cellular uptake and concentrations of tamoxifen upon administration in poly (ε-caprolactone) nanoparticles

JS Chawla, MM Amiji - Aaps Pharmsci, 2003 - Springer
Purpose: In an attempt to increase the local concentration of tamoxifen in estrogen receptor
positive breast cancer cells, we have prepared and characterized poly (ε …

Poly (ethylene oxide)-modified poly (ɛ-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer

DB Shenoy, MM Amiji - International journal of pharmaceutics, 2005 - Elsevier
This study was carried out to evaluate and compare the biodistribution profile of tamoxifen
when administered intravenously (iv) as a simple solution or when encapsulated in …

Methotrexate and Curcumin co-encapsulated PLGA nanoparticles as a potential breast cancer therapeutic system: In vitro and in vivo evaluation

MA Vakilinezhad, A Amini, T Dara, S Alipour - Colloids and Surfaces B …, 2019 - Elsevier
Nanoparticulate delivery systems have been noticed for chemotherapeutical delivery due to
their ability in controlling the drug release and reducing the side effect. These systems could …

Controlled release of tamoxifen citrate encapsulated in cross-linked guar gum nanoparticles

JK Sarmah, R Mahanta, SK Bhattacharjee… - International journal of …, 2011 - Elsevier
Natural polysaccharides, due to their outstanding merits, have received more and more
attention in the field of drug delivery. In the present study tamoxifen citrate, TMX (a non …

Revolutionizing anticancer drug delivery: Exploring the potential of tamoxifen-loaded nanoformulations

A Sani, M Pourmadadi, M Shaghaghi… - Journal of Drug Delivery …, 2023 - Elsevier
Tamoxifen (TAM), as a hydrophobic drug, is a selective estrogen modulator (SERM) applied
to hormone therapy for breast cancer (BC). Although it is effective and affordable in BC …