Epilepsy is among the most dynamic disorders in neurology. A canonical view holds that
seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans …

The cyclical organization of seizures in epilepsy has been described since antiquity.
However, historical explanations for seizure cycles—based on celestial, hormonal, and …

Recent trials of chronic EEG in humans showed that epilepsy is a cyclical disorder of the
brain with rhythms at multiple time-scales: circadian, multi-day (multidien) or even seasonal …

Personalized medicine requires that treatments adapt to not only the patient but also
changing factors within each individual. Although epilepsy is a dynamic disorder …

Epilepsy is a unique neurologic condition characterized by recurrent seizures, where
causes, underlying biomarkers, triggers, and patterns differ across individuals. The …

To date, the unpredictability of seizures remains a source of suffering for people with
epilepsy, motivating decades of research into methods to forecast seizures. Originally, only …

Epilepsy is defined by the seemingly random occurrence of spontaneous seizures. The
ability to anticipate seizures would enable preventative treatment strategies. A central but …

Growing evidence shows the bidirectional interactions between sleep, circadian rhythm, and
epilepsy. Comprehending how these interact with each other may help to advance our …

Background Epilepsy has long been suspected to be governed by cyclic rhythms, with
seizure rates rising and falling periodically over weeks, months, or even years. The very long …

Importance Focal epilepsy is characterized by the cyclical recurrence of seizures, but, to our
knowledge, the prevalence and patterns of seizure cycles are unknown. Objective To …