Abstract Dana-Farber Cancer Institute (DFCI) ALL Consortium Protocol 05-001 tested a new
risk stratification system in children and adolescents with newly diagnosed acute …

PURPOSE Children's Oncology Group (COG) AALL0331 tested whether intensified
postinduction therapy that improves survival in children with high-risk B-cell acute …

Purpose Somatic deletions that affect the lymphoid transcription factor–coding gene IKZF1
have previously been reported as independently associated with a poor prognosis in …

The added value of IKZF1 gene deletion (IKZF1 del) as a stratifying criterion in B-cell
precursor acute lymphoblastic leukemia (BCP-ALL) is still debated. We performed a …

Abstract The Children's Cancer Group (CCG) and the Pediatric Oncology Group (POG)
joined to form the Children's Oncology Group (COG) in 2000. This merger allowed analysis …

Recurrent chromosomal rearrangements carry prognostic significance in pediatric B-lineage
acute lymphoblastic leukemia (B-ALL). Recent genome-wide analyses identified a high-risk …

To determine whether gene expression profiling could improve outcome prediction in
children with acute lymphoblastic leukemia (ALL) at high risk for relapse, we profiled …

Purpose Our aim was to determine the role of end-of-induction (EOI) minimal residual
disease (MRD) assessment in the identification and stratification of induction failure in …

The survival rate of children with acute lymphoblastic leukemia (ALL) has increased to
approximately 90% after substantial progress in risk-oriented treatment strategies. Between …

To resolve the genetic heterogeneity within pediatric high-risk B-precursor acute
lymphoblastic leukemia (ALL), a clinically defined poor-risk group with few known recurring …