Objective: To assess the genetic contribution of TBK1, a gene implicated in amyotrophic
lateral sclerosis (ALS), frontotemporal dementia (FTD), and FTD-ALS, in Belgian FTD and …

Abstract TANK1-binding kinase 1 (TBK1) has been recently identified as a new amyotrophic
lateral sclerosis (ALS) gene. Loss-of-function (LoF) mutations in TBK1 could be responsible …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are related
neurodegenerative syndromes that occur sporadically or have been associated with mostly …

We investigated the mutation spectrum of the TANK‐Binding Kinase 1 (TBK1) gene and its
associated phenotypic spectrum by exonic resequencing of TBK1 in a cohort of 2,538 …

Recently, mutations in the TANK-binding kinase 1 (TBK1) gene were identified as a cause
for amyotrophic lateral sclerosis (ALS) with or without comorbid frontotemporal dementia …

We identified in a cohort of patients with frontotemporal dementia (n= 481) or amyotrophic
lateral sclerosis (n= 147), 10 index patients carrying a TBK1 loss of function mutation …

Mutations in the TBK1 gene were just recently identified to cause amyotrophic lateral
sclerosis (ALS), and their role in ALS in various populations remains unclear. The aim of this …

Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative
syndrome hallmarked by adult-onset loss of motor neurons. We performed exome …

Frontotemporal lobar degeneration with TAR DNA-binding protein 43 inclusions (FTLD-
TDP) is the most common pathology associated with frontotemporal dementia (FTD). Repeat …

Background Frontotemporal lobar degeneration (FTLD) is a neurodegenerative brain
disorder that can be accompanied by signs of amyotrophic lateral sclerosis (ALS). Objective …