The quinoline moiety remains a privileged antitubercular (anti‐TB) pharmacophore,
whereas 8‐nitrobenzothiazinones are emerging potent antimycobacterial agents with two …

In pursuit of potent anti‐TB agents active against drug resistant tuberculosis (DR‐TB), herein
we report synthesis and bio‐evaluation of a new series of isoxazole‐carboxylic acid methyl …

A series of 25 new benzothiazole–urea–quinoline hybrid compounds were synthesized
successfully via a three-step synthetic sequence involving an amidation coupling reaction as …

A series of novel morpholine, thiomorpholine and N-substituted piperazine coupled 2-
(thiophen-2-yl) dihydroquinolines 7a–p was designed and synthesized from 2-acetyl …

We screened a series of 4-anilinoquinolines and 4-anilinoquinazolines and identified novel
inhibitors of Mycobacterium tuberculosis (Mtb). The focused 4-anilinoquinoline/quinazoline …

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) remains a major global
health problem and new therapeutic antitubercular agents are urgent needed. Among the …

A series of novel benzothiazinone derivatives containing a N-(amino) piperazine moiety,
based on the structure of WAP-1902 discovered in our lab, were designed and synthesized …

A series of new benzothiazinone derivatives containing a symmetric 2-benzyl-2, 7-
diazaspiro [3.5] nonane moiety, based on the structure of LK02 discovered in our lab, were …

We reported three distinct series of novel benzothiopyranones, derived from an active
metabolite (M-1) of anti-TB agent 6b. These small molecules were evaluated for their …

The WHO has estimated that one-fourth of the world's population harbor a latent infection by
MTB, and around 100-200 million individuals eventually develop an active TB. To make …