Natural Product BO-1 as an Inner Responsive Molecule Inhibits Antimicrobial-Resistant Staphylococcus aureus via Synergism

CY Xiao, J Huang, X Liu, ZL Sun, RS Li… - ACS Infectious …, 2023 - ACS Publications
Multidrug-resistant Staphylococcus aureus, a Gram-positive bacterium that causes several
difficult-to-treat human infections, is a considerable threat to global healthcare. We …

Antimicrobial activity of nature-inspired molecules against multidrug-resistant bacteria

M Hamad, F Al-Marzooq, V Srinivasulu… - Frontiers in …, 2024 - frontiersin.org
Multidrug-resistant bacterial infections present a serious challenge to global health. In
addition to the spread of antibiotic resistance, some bacteria can form persister cells which …

Small-Molecule Potentiators for Conventional Antibiotics against Staphylococcus aureus

A Vermote, S Van Calenbergh - ACS infectious diseases, 2017 - ACS Publications
Antimicrobial resistance constitutes a global health problem, while the discovery and
development of novel antibiotics is stagnating. Methicillin-resistant Staphylococcus aureus …

[HTML][HTML] Baohuoside I inhibits virulence of multidrug-resistant Staphylococcus aureus by targeting the transcription Staphylococcus accessory regulator factor SarZ

Z Wen, C Chen, Y Shang, K Fan, P Li, C Li, J Zheng… - Phytomedicine, 2024 - Elsevier
Background Staphylococcus aureus is a versatile pathogen that can cause a wide range of
infections in humans. Biofilms play a crucial role in the pathogenicity of S. aureus and …

Synergistic Augmentation of Beta-Lactams: Exploring Quinoline-Derived Amphipathic Small Molecules as Antimicrobial Potentiators against Methicillin-Resistant …

S Ghosh, S Sen, M Jash, S Ghosh, A Jana… - ACS Infectious …, 2024 - ACS Publications
The escalation of bacterial resistance against existing therapeutic antimicrobials has
reached a critical peak, leading to the rapid emergence of multidrug-resistant strains …

Suppression of Staphylococcus aureus biofilm formation and virulence by a benzimidazole derivative, UM-C162

C Kong, CF Chee, K Richter, N Thomas… - Scientific reports, 2018 - nature.com
Staphylococcus aureus is a major cause of nosocomial infections and secretes a diverse
spectrum of virulence determinants as well as forms biofilm. The emergence of antibiotic …

L007-0069 kills Staphylococcus aureus in high resistant phenotypes

S Pengfei, L Yaqian, X Lanlan, L Zehao, L Yimin… - Cellular and Molecular …, 2022 - Springer
Staphylococcus aureus, a common gram-positive pathogenic bacterium, is a main cause of
hospital infection. The prevalence rate of methicillin-resistant S. aureus (MRSA) has made …

Microbe-Derived Indole Metabolite Demonstrates Potent Multidrug Efflux Pump Inhibition in Staphylococcus aureus

R Tambat, M Jangra, N Mahey, N Chandal… - Frontiers in …, 2019 - frontiersin.org
Efflux pumps are always at the forefront of bacterial multidrug resistance and account for the
failure of antibiotics. The present study explored the potential of 2-(2-Aminophenyl) indole …

The Fusaric Acid Derivative qy17 Inhibits Staphylococcus haemolyticus by Disrupting Biofilm Formation and the Stress Response via Altered Gene Expression

B Wang, CR Song, QY Zhang, PW Wei… - Frontiers in …, 2022 - frontiersin.org
Staphylococcus haemolyticus (S. haemolyticus) is the second most commonly isolated
coagulase-negative staphylococcus (CoNS) in patients with hospital-acquired infections. It …

Antibacterial sensitizers from natural plants: A powerful weapon against methicillin-resistant Staphylococcus aureus

X Li, Y Cai, Q Xia, Y Liao, R Qin - Frontiers in Pharmacology, 2023 - frontiersin.org
Methicillin-resistant Staphylococcus aureus (MRSA) is a drug-resistant bacterium that can
cause a range of infections with high morbidity and mortality, including pneumonia, etc …