Interaction of modified oligonucleotides with nuclear proteins, formation of novel nuclear structures and sequence-independent effects on RNA processing
Oligonucleotides and nucleic acid analogues that alter gene expression are showing
therapeutic promise for selected human diseases. The modification of synthetic nucleic …
therapeutic promise for selected human diseases. The modification of synthetic nucleic …
Single stranded fully modified-phosphorothioate oligonucleotides can induce structured nuclear inclusions, alter nuclear protein localization and disturb the …
Oligonucleotides and nucleic acid analogues that alter gene expression are now showing
therapeutic promise in human disease. Whilst the modification of synthetic nucleic acids to …
therapeutic promise in human disease. Whilst the modification of synthetic nucleic acids to …
[PDF][PDF] Single Stranded Fully Modified-Phosphorothioate Oligonucleotides can Induce Structured Nuclear Inclusions, Alter Nuclear Protein Localization and Disturb the …
LL Flynn, R Li, IL Pitout… - Frontiers in …, 2022 - researchportal.murdoch.edu.au
Antisense oligonucleotide (AO) drugs are a class of therapeutics designed to alter gene
expression through binding RNA.'RNase H1 activating'AOs contain modified chemical …
expression through binding RNA.'RNase H1 activating'AOs contain modified chemical …
Off-target effects and safety aspects of phosphorothioate oligonucleotides
M Stessl, CR Noe, J Winkler - From Nucleic Acids Sequences to Molecular …, 2012 - Springer
In addition to the intended sequence-specific downregulation of the gene target, antisense
and siRNA oligonucleotides can trigger off-target effects that are often caused by a particular …
and siRNA oligonucleotides can trigger off-target effects that are often caused by a particular …
Off‐target effects related to the phosphorothioate modification of nucleic acids
J Winkler, M Stessl, J Amartey, CR Noe - ChemMedChem, 2010 - Wiley Online Library
Phosphorothioate antisense oligonucleotides have been widely used in clinical studies for
rational sequence‐specific gene silencing. However, several sequence‐unspecific off‐target …
rational sequence‐specific gene silencing. However, several sequence‐unspecific off‐target …
Beyond ribose and phosphate: selected nucleic acid modifications for structure–function investigations and therapeutic applications
C Liczner, K Duke, G Juneau, M Egli… - Beilstein Journal of …, 2021 - beilstein-journals.org
Over the past 25 years, the acceleration of achievements in the development of
oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the …
oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the …
Sequence- and Structure-Dependent Cytotoxicity of Phosphorothioate and 2′-O-Methyl Modified Single-Stranded Oligonucleotides
LV Croft, M Fisher, TK Barbhuiya… - nucleic acid …, 2024 - liebertpub.com
Single-stranded oligonucleotides (SSOs) are a rapidly expanding class of therapeutics that
comprises antisense oligonucleotides, microRNAs, and aptamers, with ten clinically …
comprises antisense oligonucleotides, microRNAs, and aptamers, with ten clinically …
Phosphorothioate oligodeoxynucleotides—anti-sense inhibitors of gene expression?
CA Stein, JL Tonkinson, L Yakubov - Pharmacology & therapeutics, 1991 - Elsevier
Phosphorothioate (PS) oligodeoxynucleotides are relatively nuclease resistant, water
soluble analogs of phosphodiester (PO) oligodeoxynucleotides. These molecules are chiral …
soluble analogs of phosphodiester (PO) oligodeoxynucleotides. These molecules are chiral …
In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3′ and 5′ thiophosphate linkages
J Duschmalé, HF Hansen, M Duschmalé… - Nucleic Acids …, 2020 - academic.oup.com
The introduction of non-bridging phosphorothioate (PS) linkages in oligonucleotides has
been instrumental for the development of RNA therapeutics and antisense oligonucleotides …
been instrumental for the development of RNA therapeutics and antisense oligonucleotides …
Mesyl phosphoramidate antisense oligonucleotides as an alternative to phosphorothioates with improved biochemical and biological properties
SK Miroshnichenko, OA Patutina… - Proceedings of the …, 2019 - National Acad Sciences
Here we describe a DNA analog in which the mesyl (methanesulfonyl) phosphoramidate
group is substituted for the natural phosphodiester group at each internucleotidic position …
group is substituted for the natural phosphodiester group at each internucleotidic position …