Molecular medicine has entered a high-tech age that provides curative treatments of
complex genetic diseases through genetically engineered cellular medicinal products. Their …

Widespread treatment of human diseases with gene therapies necessitates the
development of gene transfer vectors that integrate genetic information effectively, safely …

Effective gene therapy requires robust delivery of therapeutic genes into relevant target
cells, long-term gene expression, and minimal risks of secondary effects. Nonviral gene …

Recent results confirm that long‐term expression of therapeutic transgenes can be achieved
by using a transposon‐based system in primary stem cells and in vivo. Transposable …

Sleeping Beauty (SB) is the first synthetic DNA transposon that was shown to be active in a
wide variety of species. Here, we review studies from the last two decades addressing both …

The widespread clinical implementation of gene therapy requires the ability to stably
integrate genetic information through gene transfer vectors in a safe, effective, and …

Transposable elements can be considered as natural, non-viral gene delivery vehicles
capable of efficient genomic insertion. The plasmid-based transposon system of Sleeping …

Abstract The Sleeping Beauty transposon system is a nonviral DNA transfer tool capable of
efficiently mediating transposition‐based, stable integration of DNA sequences of choice …

Transposable elements can be viewed as natural DNA transfer vehicles that, similar to
integrating viruses, are capable of efficient genomic insertion. The mobility of class II …

Over the past decade, the Sleeping Beauty (SB) transposon system has been developed as
the leading non-viral vector for gene therapy. This vector combines the advantages of …