In this paper we review the mechanisms of the antitumor effects of Hypericum perforatum
L.(St. John's wort, SJW) and its main active component hyperforin (HPF). SJW extract is …

Hyperforin (HPF), the main component responsible for the antidepressant action of
Hypericum perforatum, displays additional beneficial properties including anti-inflammatory …

Oxidative stress and the hypoxic microenvironment play a key role in the progression of
human melanoma, one of the most aggressive skin cancers. The aim of our study was to …

Hyperforin (HP) is an abundant component of St John's wort with antibiotic and
antidepressive activity. We report here the ability of HP and that of polyphenolic procyanidin …

Extracts of the plant St John's wort, Hyperforin perforatum L., have been used for centuries in
traditional medicine, notably for the treatment of depression. One of their main lipophilic …

Background The natural phloroglucinol hyperforin HF displays anti-inflammatory and anti-
tumoral properties of potential pharmacological interest. Acute myeloid leukemia (AML) cells …

Xanthohumol is a prenylflavonoid extracted from hops (Humulus lupulus). It possesses anti-
cancer and anti-inflammatory activities in vitro and in vivo, and offers therapeutic benefits for …

Hyperforin (Hyp) is an active compound contained in the extract of Hypericum perforatum,
well known for its antidepressant activity. However, Hyp has been found to possess several …

Perillyl alcohol (POH) is a dietary monoterpene present in a variety of plants with a pure or
mixed form, and it is one of the very few natural substances with anticancer activity …

Diabetes mellitus is a very common chronic disease with progressively increasing
prevalence. Besides the well-known autoimmune and inflammatory pathogenesis of type 1 …