Microglia, the primary immune cells of the central nervous system (CNS), are derived from
the yolk sac and populate the brain during development. Once microglia migrate to the CNS …

Microglia, the resident macrophages of the central nervous system (CNS), play a critical role
in CNS homeostasis and neuroinflammation. Pexidartinib (PLX3397), a colony-stimulating …

Microglia are the principal resident immune cells in the central nervous system (CNS) and
play important roles in CNS development, maintenance and repair. The survival and …

Microglia activation and proliferation are hallmarks of many neurodegenerative disorders
and may contribute to disease pathogenesis. Neurons actively regulate microglia survival …

Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous
system (CNS). While multiple effective immunomodulatory therapies for MS exist today, they …

Microglia, predominant parenchymal resident macrophages in the central nervous system
(CNS), are crucial players in neurodevelopment and CNS homeostasis. In disease …

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system
(CNS) characterized by progressive neuronal demyelination and degeneration. Much of this …

Graft-versus-host disease (GVHD) is a serious complication of otherwise curative allogeneic
haematopoietic stem cell transplants. Chronic GVHD induces pathological changes in …

The receptor for colony stimulating factor 1 (CSF-1R) is important for the survival and
function of myeloid cells that mediate pathology during experimental autoimmune …

Astrocytes are the most abundant cells in the CNS parenchyma and play an essential role in
several brain functions, such as the fine-tuning of synaptic transmission, glutamate uptake …