Antibiotic resistance mechanisms in M. tuberculosis: an update

L Nguyen - Archives of toxicology, 2016 - Springer
Abstract Treatment of tuberculosis (TB) has been a therapeutic challenge because of not
only the naturally high resistance level of Mycobacterium tuberculosis to antibiotics but also …

Molecular Biology of Drug Resistance in Mycobacterium tuberculosis

T Smith, KA Wolff, L Nguyen - … tuberculosis and its Interaction with the …, 2012 - Springer
Tuberculosis (TB) has become a curable disease, thanks to the discovery of antibiotics.
However, it has remained one of the most difficult infections to treat. Most current TB …

[HTML][HTML] The complex evolution of antibiotic resistance in Mycobacterium tuberculosis

JD Fonseca, GM Knight, TD McHugh - International journal of infectious …, 2015 - Elsevier
Multidrug-resistant and extensively drug-resistant tuberculosis (TB) represent a major threat
to the control of the disease worldwide. The mechanisms and pathways that result in the …

Mechanisms of drug resistance in Mycobacterium tuberculosis: update 2015

Y Zhang, WW Yew - … Journal of Tuberculosis and Lung Disease, 2015 - ingentaconnect.com
Drug-resistant tuberculosis (DR-TB), including multi-and extensively drug-resistant TB, is
posing a significant challenge to effective treatment and TB control worldwide. New progress …

[HTML][HTML] Unraveling the mechanisms of intrinsic drug resistance in Mycobacterium tuberculosis

NC Poulton, JM Rock - Frontiers in cellular and infection microbiology, 2022 - frontiersin.org
Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of
multidrug therapy to produce a durable cure. The reasons necessitating long treatment times …

Drug-resistance in Mycobacterium tuberculosis: where we stand

A Mabhula, V Singh - Medchemcomm, 2019 - pubs.rsc.org
Tuberculosis (TB), an infectious disease caused by the bacterium Mycobacterium
tuberculosis (Mtb), has burdened vulnerable populations in modern day societies for …

Drug resistant Tuberculosis: A review

JL Khawbung, D Nath, S Chakraborty - … immunology, microbiology and …, 2021 - Elsevier
Tuberculosis (TB) was announced as a global emergency in 1993. There was an alarming
counter attack of TB worldwide. However, when it was known that TB can be cured …

Mycobacterial subversion of chemotherapeutic reagents and host defense tactics: challenges in tuberculosis drug development

L Nguyen, J Pieters - Annual review of pharmacology and …, 2009 - annualreviews.org
Recent worldwide emergence of multidrug-resistant and extensively drug-resistant
tuberculosis is threatening to destabilize tuberculosis control programs and urging global …

Molecular basis and mechanisms of drug resistance in Mycobacterium tuberculosis: classical and new drugs

PE Almeida Da Silva… - Journal of antimicrobial …, 2011 - academic.oup.com
Tuberculosis (TB) remains one of the leading public health problems worldwide. Declared
as a global emergency in 1993 by the WHO, its control is hampered by the emergence of …

[HTML][HTML] Tackling Drug-Resistant Tuberculosis: New Challenges from the Old Pathogen Mycobacterium tuberculosis

G Mancuso, A Midiri, S De Gaetano, E Ponzo… - Microorganisms, 2023 - mdpi.com
Antibiotics have played a crucial role in the reduction in the incidence of TB globally as
evidenced by the fact that before the mid-20th century, the mortality rate within five years of …