Detecting natural selection in genomic data

JJ Vitti, SR Grossman, PC Sabeti - Annual review of genetics, 2013 - annualreviews.org
The past fifty years have seen the development and application of numerous statistical
methods to identify genomic regions that appear to be shaped by natural selection. These …

Thinking too positive? Revisiting current methods of population genetic selection inference

C Bank, GB Ewing, A Ferrer-Admettla, M Foll… - Trends in Genetics, 2014 - cell.com
In the age of next-generation sequencing, the availability of increasing amounts and
improved quality of data at decreasing cost ought to allow for a better understanding of how …

Interrogating a high-density SNP map for signatures of natural selection

JM Akey, G Zhang, K Zhang, L Jin… - Genome research, 2002 - genome.cshlp.org
Identifying genomic regions that have been targets of natural selection remains one of the
most important and challenging areas of research in genetics. To this end, we report an …

[HTML][HTML] Population history and natural selection shape patterns of genetic variation in 132 genes

JM Akey, MA Eberle, MJ Rieder, CS Carlson… - PLoS …, 2004 - journals.plos.org
Identifying regions of the human genome that have been targets of natural selection will
provide important insights into human evolutionary history and may facilitate the …

A genome scan to detect candidate regions influenced by local natural selection in human populations

M Kayser, S Brauer, M Stoneking - Molecular Biology and …, 2003 - academic.oup.com
As human populations dispersed throughout the world, they were subjected to new selective
forces, which must have led to local adaptation via natural selection and hence altered …

Molecular signatures of natural selection

R Nielsen - Annu. Rev. Genet., 2005 - annualreviews.org
There is an increasing interest in detecting genes, or genomic regions, that have been
targeted by natural selection. The interest stems from a basic desire to learn more about …

Recent and ongoing selection in the human genome

R Nielsen, I Hellmann, M Hubisz… - Nature Reviews …, 2007 - nature.com
The recent availability of genome-scale genotyping data has led to the identification of
regions of the human genome that seem to have been targeted by selection. These findings …

1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans

M Pybus, GM Dall'Olio, P Luisi, M Uzkudun… - Nucleic acids …, 2014 - academic.oup.com
Searching for Darwinian selection in natural populations has been the focus of a multitude of
studies over the last decades. Here we present the 1000 Genomes Selection Browser 1.0 …

Genomic signatures of positive selection in humans and the limits of outlier approaches

JL Kelley, J Madeoy, JC Calhoun, W Swanson… - Genome …, 2006 - genome.cshlp.org
Identifying regions of the human genome that have been targets of positive selection will
provide important insights into recent human evolutionary history and may facilitate the …

Detecting the form of selection from DNA sequence data

SP Otto - Trends in Genetics, 2000 - cell.com
Clues to our evolutionary history lie hidden within DNA sequence data. One of the great
challenges facing population geneticists is to identify and accurately interpret these clues …