Its semi-allogeneic nature renders the conceptus vulnerable to attack by the maternal
immune system. Several protective mechanisms operate during gestation to correct the …

BACKGROUND Adaptation of the maternal immune response to accommodate the semi-
allogeneic fetus is necessary for pregnancy success, and disturbances in maternal tolerance …

Citation Leber A, Teles A, Zenclussen AC. Regulatory T cells and their role in pregnancy.
Am J Reprod Immunol 2010 Regulatory T cells emerge in the last years as key players in …

PROBLEM: This study was aimed at investigating the involvement of an altered cytokine
pattern in the immunomodulatory and anti‐abortive effects of a progesterone‐induced …

Immunological mechanisms play a pivotal role in the pathophysiology of preeclampsia. T
regulatory cells (Treg cells, FoxP3+) suppress the cytotoxic T cell (CD8+) and natural killer …

Regulatory T cells (Tregs) are a specialized subset of T lymphocytes that function as
suppressive immune cells and inhibit various elements of immune response in vitro and in …

Semi-allogenic fetuses are not rejected by the maternal immune system because feto-
maternal tolerance induced by CD4+ CD25+ FoxP3+ regulatory T (Treg) cells is established …

Establishment and maintenance of pregnancy represents a challenge for the maternal
immune system since it has to defend against pathogens and tolerate paternal alloantigens …

Maternal immune system must tolerate semiallogenic fetus to establish and maintain a
successful pregnancy. Despite the existence of several strategies of trophoblast to avoid …

Tolerance mechanisms are responsible for the survival of the fetus within the maternal
uterus without being attacked by the cells of the maternal immune system despite their direct …