Traditionally, the analgesic action of nonsteroidal anti-inflammatory drugs (NSAIDs) has
been explained on the basis of their inhibition of the enzymes that synthesise …

Salicylic acid and salicylates, obtained from natural sources, have long been used as
medicaments. Salicylic acid was chemically synthesized in 1860 and was used as an …

Non-steroidal anti-inflammatory drugs (NSAIDs) including both traditional non-selective
NSAIDs and the selective cyclooxygenase (COX)-2 inhibitors, are widely used for their anti …

The popular view that all nonsteroidal anti-inflammatory drugs (NSAIDs) act by inhibiting the
production of prostaglandins has been challenged by the discovery that they also affect a …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of agents with similar actions but
diverse chemical structures. Aspirin (acetylsalicylic acid) and sodium salicylate were the first …

Nonsteroid antiinflammatory drugs (NSAIDs) or aspirin-like drugs act by inhibiting the activity
of the cyclooxygenase (COX) enzyme. Two isoforms of COX exist, COX-1, which is …

Non-steroidal anti-inflammatory drugs (NSAIDs), which act via inhibition of the
cyclooxygenase (COX) isozymes, were discovered more than 100 years ago. They remain a …

Despite the diverse chemical structure of aspirin-like drugs, the antinociceptive effect of
NSAIDs is mainly due to their common property of inhibiting cyclooxygenases involved in …

Non‐steroidal anti‐inflammatory drugs (NSAID s) are a chemically heterogeneous group of
compounds that provide unmistakable and significant health benefits in the treatment of pain …

Rheumatic diseases are the most prevalent causes of disability in western countries, and
non-steroidal anti-inflammatory drugs (NSAIDs) are still the most commonly used remedies …