Construction of pH‐Dependent Nanozymes with Oxygen Vacancies as the High‐Efficient Reactive Oxygen Species Scavenger for Oral‐Administrated Anti …

N Zhao, FE Yang, CY Zhao, SW Lv… - Advanced …, 2021 - Wiley Online Library
It is of great significance to eliminate excessive reactive oxygen species (ROS) for treating
inflammatory bowel disease (IBD). Herein, for the first time, a novel nanozyme NiCo2O4 …

A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease

F Zeng, Y Shi, C Wu, J Liang, Q Zhong, K Briley… - Journal of …, 2022 - Springer
Inflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a
lack of effective therapeutic strategies. The proinflammatory microenvironment plays a …

Oral nanozyme-engineered probiotics for the treatment of ulcerative colitis

H Zhao, Y Du, L Liu, Y Du, K Cui, P Yu, L Li… - Journal of Materials …, 2022 - pubs.rsc.org
Probiotic-based therapy for ulcerative colitis (UC) is a novel and promising approach that
has gained much popularity in recent years. However, probiotics may be easily captured …

Multifunctional nanozyme hydrogel with mucosal healing activity for single-dose ulcerative colitis therapy

C Cheng, Y Cheng, S Zhao, Q Wang, S Li… - Bioconjugate …, 2021 - ACS Publications
Nanozymes are nanomaterials with enzyme-like activities, which have been developed for
inflammatory disease therapy by reactive oxygen species (ROS) scavenging. The …

Integrated cascade nanozyme catalyzes in vivo ROS scavenging for anti-inflammatory therapy

Y Liu, Y Cheng, H Zhang, M Zhou, Y Yu, S Lin… - Science …, 2020 - science.org
Here, an integrated cascade nanozyme with a formulation of Pt@ PCN222-Mn is developed
to eliminate excessive reactive oxygen species (ROS). This nanozyme mimics superoxide …

One-pot synthesis of Fe/N-doped hollow carbon nanospheres with multienzyme mimic activities against inflammation

L Fan, P Sun, Y Huang, Z Xu, X Lu, J Xi… - ACS Applied Bio …, 2020 - ACS Publications
Inflammation, including infectious and noninfectious inflammation, are a growing threat to
public health worldwide. For different types of inflammation, more specific and intensified …

Ultrasmall Cu2O@His Nanozymes with RONS Scavenging Capability for Anti-inflammatory Therapy

S Li, Z Chen, M Wang, F Yang, S Zhang… - … Applied Materials & …, 2024 - ACS Publications
High concentrations of reactive oxygen and nitrogen species (RONS) are key characteristics
of inflammatory sites. Scavenging RONS at the site of inflammation is an effective …

[HTML][HTML] Sulfasalazine-loaded nanoparticles for efficient inflammatory bowel disease therapy via ROS-scavenging strategy

S Lin, H Zhao, C Xu, P Zhang, X Mei, D Jiang - Materials & Design, 2023 - Elsevier
Inflammatory bowel disease (IBD) is a life-threatening organ dysfunction amplified by
complex interactions between genetic, environmental, and immune factors. Sulfasalazine …

Macrophage-biomimetic liposomes delivery of carbon dots nanozymes ameliorate ulcerative colitis by modulating inflammation pathways and remodeling the redox …

Y Ma, J Zhao, Z Deng, B Gao, C Xu, X Yan… - Chemical Engineering …, 2023 - Elsevier
As a recurrent chronic inflammatory intestinal disease, ulcerative colitis (UC) has seriously
affected the life quality of patients. Numerous studies have demonstrated excessive reactive …

Rational design of orally administered cascade nanozyme for inflammatory bowel disease therapy

Y Yu, X Zhao, X Xu, C Cai, X Tang, Q Zhang… - Advanced …, 2023 - Wiley Online Library
Inflammatory bowel disease (IBD) affects millions of individuals worldwide annually. Enteric
reactive oxygen species (ROS) play critical roles in the physiology and pathology of IBD …