CD4+ T lymphocytes have been classified into several lineages, according to their gene
expression profiles and their effector responses. Interestingly, recent evidence is showing …

T cell/B cell mixed phenotypic lymphocytes have been observed in different disease
contexts, yet their presence and function in physiological conditions remain elusive. Here …

Abstract CD4+/CD8+ DP thymocytes are a well-described T cell developmental stage within
the thymus. However, once differentiated, the CD4+ lineage or the CD8+ lineage is …

Increasing evidence shows pathophysiological significance of rare immune cells,
necessitating the need for reliable and proper methods for their detection and analysis. We …

During the past two decades of research in T cell biology, an increasing number of distinct T
cell subsets arising during the transition from naïve to antigen-experienced T cells have …

CD4+ helper T cells play crucial roles for host defense and immune-mediated disease by
their ability to differentiate into specialized subsets. These subsets attain restricted patterns …

This review builds on evidence that cell‐mediated immune responses to bacteria, viruses,
parasites, and tumors are an integration of conventional and unconventional T‐cell …

MHC-E restricted CD8 T cells show promise in vaccine settings, but their development and
specificity remain poorly understood. Here we focus on a CD8 T cell population reactive to a …

CD 4+ T cells are critical for the elimination of an immense array of microbial pathogens.
Among the ways they accomplish this task is to generate progeny with specialized …

It is well established that CD8+ T cells constitute an important branch of adaptive immunity
contributing to clearance of intracellular pathogens and providing long-term protection …