Molecular mechanism operating in animal models of neurogenic detrusor overactivity: A systematic review focusing on bladder dysfunction of neurogenic origin

A Ferreira, D Nascimento, CD Cruz - International Journal of Molecular …, 2023 - mdpi.com
Neurogenic detrusor overactivity (NDO) is a severe lower urinary tract disorder,
characterized by urinary urgency, retention, and incontinence, as a result of a neurologic …

Detrusor underactivity: a plea for new approaches to a common bladder dysfunction

GA Van Koeveringe, B Vahabi… - Neurourology and …, 2011 - Wiley Online Library
Aims Detrusor underactivity (DU) is defined by the International Continence Society as a
contraction of reduced strength and/or duration resulting in prolonged or incomplete …

A ventral root avulsion injury model for neurogenic underactive bladder studies

HH Chang, LA Havton - Experimental neurology, 2016 - Elsevier
Detrusor underactivity (DU) is defined as a contraction of reduced strength and/or duration
during bladder emptying and results in incomplete and prolonged bladder emptying. The …

Nerve sprouting and neurogenic inflammation characterize the neurogenic detrusor overactive bladder of patients no longer responsive to drug therapies

C Traini, G Del Popolo… - Journal of Cellular …, 2019 - Wiley Online Library
Abstract Urothelium and Lamina Propria (LP) are considered an integrate sensory system
which is able to control the detrusor activity. Complete supra‐sacral spinal cord lesions …

Functional and molecular characterisation of the bilateral pelvic nerve crush injury rat model for neurogenic detrusor underactivity

K Dewulf, E Weyne, T Gevaert, Y Deruyver… - BJU …, 2019 - Wiley Online Library
Objectives To create a rat model for neurogenic detrusor underactivity (DU) by bilateral
pelvic nerve crush injury (BPNI) and to study temporal changes in detrusor contractility and …

Pharmacological and genetic analysis of mechanisms underlying detrusor overactivity in rats

O Yokoyama - … and Urodynamics: Official Journal of the …, 2010 - Wiley Online Library
Aims Suprapontine lesions, such as those resulting from cerebrovascular disease, cause
bladder storage dysfunction. Detrusor overactivity (DO) following cerebral infarction may be …

Molecular characterization of non-neurogenic and neurogenic lower urinary tract dysfunction (LUTD) in SCI-induced and partial bladder outlet obstruction mouse …

M von Siebenthal, A Akshay, M Besic… - International journal of …, 2023 - mdpi.com
We examined bladder function following spinal cord injury (SCI) by repeated urodynamic
investigation (UDI), including external urethral sphincter (EUS) electromyography (EMG) in …

Dysfunctional voiding behavior and impaired muscle contractility in a rat model of detrusor underactivity

EJ Gonzalez, MR Odom, JL Hannan… - Neurourology and …, 2021 - Wiley Online Library
Aims Detrusor underactivity (DU) is an understudied health concern with inadequate clinical
management. The pathophysiology of DU is unclear, and current therapies fail to improve …

Neurogenic causes of detrusor underactivity

BT Kadow, P Tyagi, CJ Chermansky - Current bladder dysfunction reports, 2015 - Springer
Detrusor underactivity (DU) is a poorly understood dysfunction of the lower urinary tract
which arises from multiple etiologies. Symptoms of DU are non-specific, and a pressure-flow …

CNS involvement in overactive bladder: pathophysiology and opportunities for pharmacological intervention

KE Andersson, R Pehrson - Drugs, 2003 - Springer
The pathophysiology of overactive bladder (OAB) syndrome is complex, and involves both
peripheral and CNS factors. Several CNS disorders are associated with OAB, eg stroke …