Studies of families with breast cancer have indicated that male carriers of BRCA2 mutations
are at increased risk of prostate cancer, particularly at an early age. To evaluate the …

Studies of families who segregate BRCA2 mutations have found that men who carry disease-
associated mutations have an increased risk of prostate cancer, particularly early-onset …

Purpose: Protein-truncating mutations in BRCA1 and in particular BRCA2 genes have been
associated with prostate cancer. However, there is still uncertainty about the magnitude of …

Background: A family history of prostate cancer (PrCa) is a strong risk factor for the disease,
indicating that inherited factors are important in this disease. We previously estimated that …

Abstract Purpose: The Breast Cancer Linkage Consortium and other family-based
ascertainments have suggested that male carriers of BRCA mutations are at increased risk …

Predisposition to prostate cancer has a genetic component, and there are reports of familial
clustering of breast and prostate cancer. Two highly penetrant genes that predispose …

Background BRCA1 and BRCA2 mutations have been associated with prostate cancer
(PCa) risk but a wide range of risk estimates have been reported that are based on …

Molecular genetic analysis of prostate cancer has gained considerable attention in recent
years. The hope is to find genetic markers that can help to determine which patients are …

Background: Prostate cancer (PrCa) is one of the most common cancers affecting men but
its aetiology is poorly understood. Family history of PrCa, particularly at a young age, is a …

Background Mutations in the BRCA2 gene are associated with an increased risk of prostate
cancer, but it is not known whether they are associated with progression of the disease. We …