Convergent strategies in total syntheses of complex terpenoids
D Urabe, T Asaba, M Inoue - Chemical Reviews, 2015 - ACS Publications
One of the largest classes of naturally occurring bioactive compounds, the terpenoids, is of
extraordinary pharmacological importance. 1, 2 The sphere of activity of terpenoids covers …
extraordinary pharmacological importance. 1, 2 The sphere of activity of terpenoids covers …
Total synthesis of complex terpenoids employing radical cascade processes
K Hung, X Hu, TJ Maimone - Natural product reports, 2018 - pubs.rsc.org
Covering: 2011–2017 Radical cyclizations have a rich history in organic chemistry and have
been particularly generous to the field of natural product synthesis. Owing to their ability to …
been particularly generous to the field of natural product synthesis. Owing to their ability to …
Biomimetic dearomatization strategies in the total synthesis of meroterpenoid natural products
JH George - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Natural products are biosynthesized from a limited pool of starting materials via
pathways that obey the same chemical logic as textbook organic reactions. Given the …
pathways that obey the same chemical logic as textbook organic reactions. Given the …
Bioinspired terpene synthesis: a radical approach
This tutorial review highlights the development of radical-based bioinspired synthesis of
terpenes from the initial proposal to the development of modern catalytic methods for …
terpenes from the initial proposal to the development of modern catalytic methods for …
Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery
DJ Jansen, RA Shenvi - Future medicinal chemistry, 2014 - Taylor & Francis
Terpenoids constitute a significant fraction of molecules produced by living organisms that
have found use in medicine and other industries. Problems associated with their …
have found use in medicine and other industries. Problems associated with their …
Modern synthetic efforts toward biologically active terpenes
TJ Maimone, PS Baran - Nature chemical biology, 2007 - nature.com
Terpenes represent one of the largest and most diverse classes of secondary metabolites,
with over 55,000 members isolated to date. The terpene cyclase enzymes used in nature …
with over 55,000 members isolated to date. The terpene cyclase enzymes used in nature …
Terpenoid‐alkaloids: their biosynthetic twist of fate and total synthesis
EC Cherney, PS Baran - Israel journal of chemistry, 2011 - Wiley Online Library
Terpenes and alkaloids are ever‐growing classes of natural products that provide new
molecular structures that inspire chemists and possess a broad range of biological activity …
molecular structures that inspire chemists and possess a broad range of biological activity …
Modular chemoenzymatic synthesis of terpenes and their analogues
LA Johnson, A Dunbabin, JCR Benton… - Angewandte Chemie …, 2020 - Wiley Online Library
Non‐natural terpenoids offer potential as pharmaceuticals and agrochemicals. However,
their chemical syntheses are often long, complex, and not easily amenable to large‐scale …
their chemical syntheses are often long, complex, and not easily amenable to large‐scale …
Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro
Terpenoids constitute a large and diverse class of natural products that serve many
functions in nature. Most of the tens of thousands of the discovered terpenoids are …
functions in nature. Most of the tens of thousands of the discovered terpenoids are …
Biogenetic-type rearrangements of terpenes
A remarkable characteristic of naturally occurring terpenes is the bewildering array of
carbocyclic structures. As of 1970 more than 200 different carbon skeletons had been …
carbocyclic structures. As of 1970 more than 200 different carbon skeletons had been …