Convergent strategies in total syntheses of complex terpenoids

D Urabe, T Asaba, M Inoue - Chemical Reviews, 2015 - ACS Publications
One of the largest classes of naturally occurring bioactive compounds, the terpenoids, is of
extraordinary pharmacological importance. 1, 2 The sphere of activity of terpenoids covers …

Total synthesis of complex terpenoids employing radical cascade processes

K Hung, X Hu, TJ Maimone - Natural product reports, 2018 - pubs.rsc.org
Covering: 2011–2017 Radical cyclizations have a rich history in organic chemistry and have
been particularly generous to the field of natural product synthesis. Owing to their ability to …

Biomimetic dearomatization strategies in the total synthesis of meroterpenoid natural products

JH George - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Natural products are biosynthesized from a limited pool of starting materials via
pathways that obey the same chemical logic as textbook organic reactions. Given the …

Bioinspired terpene synthesis: a radical approach

J Justicia, LA de Cienfuegos, AG Campana… - Chemical Society …, 2011 - pubs.rsc.org
This tutorial review highlights the development of radical-based bioinspired synthesis of
terpenes from the initial proposal to the development of modern catalytic methods for …

Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery

DJ Jansen, RA Shenvi - Future medicinal chemistry, 2014 - Taylor & Francis
Terpenoids constitute a significant fraction of molecules produced by living organisms that
have found use in medicine and other industries. Problems associated with their …

Modern synthetic efforts toward biologically active terpenes

TJ Maimone, PS Baran - Nature chemical biology, 2007 - nature.com
Terpenes represent one of the largest and most diverse classes of secondary metabolites,
with over 55,000 members isolated to date. The terpene cyclase enzymes used in nature …

Terpenoid‐alkaloids: their biosynthetic twist of fate and total synthesis

EC Cherney, PS Baran - Israel journal of chemistry, 2011 - Wiley Online Library
Terpenes and alkaloids are ever‐growing classes of natural products that provide new
molecular structures that inspire chemists and possess a broad range of biological activity …

Modular chemoenzymatic synthesis of terpenes and their analogues

LA Johnson, A Dunbabin, JCR Benton… - Angewandte Chemie …, 2020 - Wiley Online Library
Non‐natural terpenoids offer potential as pharmaceuticals and agrochemicals. However,
their chemical syntheses are often long, complex, and not easily amenable to large‐scale …

Bioengineering of plant (tri)terpenoids: from metabolic engineering of plants to synthetic biology in vivo and in vitro

T Moses, J Pollier, JM Thevelein… - New Phytologist, 2013 - Wiley Online Library
Terpenoids constitute a large and diverse class of natural products that serve many
functions in nature. Most of the tens of thousands of the discovered terpenoids are …

Biogenetic-type rearrangements of terpenes

G Cimino, RM Coates, S De Stefano, A Fontana… - Fortschritte der Chemie …, 1976 - Springer
A remarkable characteristic of naturally occurring terpenes is the bewildering array of
carbocyclic structures. As of 1970 more than 200 different carbon skeletons had been …