Immunoneutralization of human angiotensin-(1-12) with a monoclonal antibody in a humanized model of hypertension
CM Ferrario, JL VonCannon, J Zhang, JP Figueroa… - Peptides, 2022 - Elsevier
We engineered a monoclonal antibody (mAb) against the human C-terminus of angiotensin-
(1–12)[h-Ang-(1–12)] and performed a biochemical characterization in concert with direct in …
(1–12)[h-Ang-(1–12)] and performed a biochemical characterization in concert with direct in …
Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2) 27 hypertensive rats
K Isa, MA García-Espinosa, AC Arnold… - American Journal …, 2009 - journals.physiology.org
Angiotensin-(1-12)[ANG-(1-12)] is a newly identified peptide detected in a variety of rat
tissues, including the brain. To determine whether brain ANG-(1-12) participates in blood …
tissues, including the brain. To determine whether brain ANG-(1-12) participates in blood …
Opposing actions of angiotensin-(1-7) and angiotensin II in the brain of transgenic hypertensive rats
A Moriguchi, EA Tallant, K Matsumura, TM Reilly… - …, 1995 - Am Heart Assoc
Lack of specific antagonists to the amino-terminal heptapeptide angiotensin-(1-7)[Ang-(1-7)]
prompted us to evaluate the central effects of delivering a specific affinity-purified Ang-(1-7) …
prompted us to evaluate the central effects of delivering a specific affinity-purified Ang-(1-7) …
Antihypertensive actions of angiotensin-(1-7) in spontaneously hypertensive rats
IF Benter, CM Ferrario, M Morris… - American Journal of …, 1995 - journals.physiology.org
Observations that angiotensin-(1-7)[ANG-(1-7)] may oppose the vasoconstrictor actions of
angiotensin II (ANG II) prompted an investigation of the effects of the heptapeptide on the …
angiotensin II (ANG II) prompted an investigation of the effects of the heptapeptide on the …
Cardiovascular effects of angiotensin-(1–7) in conscious spontaneously hypertensive rats
RE Widdop, DB Sampey, B Jarrott - Hypertension, 1999 - Am Heart Assoc
In the present study, we reassessed whether angiotensin (Ang)-(1–7) can exert short-and
long-term cardiovascular effects because there has been a resurgence of interest in this N …
long-term cardiovascular effects because there has been a resurgence of interest in this N …
Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats
JA Jessup, AJ Trask, MC Chappell… - American Journal …, 2008 - journals.physiology.org
A low expression of angiotensinogen in the heart has been construed as indicating a
circulating uptake mechanism to explain the local effects of angiotensin II on tissues. The …
circulating uptake mechanism to explain the local effects of angiotensin II on tissues. The …
Counterregulatory actions of angiotensin-(1-7)
CM Ferrario, MC Chappell, EA Tallant… - …, 1997 - Am Heart Assoc
Abstract Angiotensin (Ang)-(1-7) is a bioactive component of the renin-angiotensin system
that is formed endogenously from either Ang I or Ang II. The first actions described for Ang-(1 …
that is formed endogenously from either Ang I or Ang II. The first actions described for Ang-(1 …
Angiotensin peptides: ready to re (de) fine the angiotensin system?
AJM Roks, RH Henning - Journal of hypertension, 2003 - journals.lww.com
During the last decade, knowledge of the actions of the various angiotensin peptides on the
cardiovascular system has dramatically increased. In addition to angiotensin II, the actions of …
cardiovascular system has dramatically increased. In addition to angiotensin II, the actions of …
Angiotensin-(1-12): does it exist? A critical evaluation in humans, rats, and mice
AF Rodrigues, O Domenig, M Poglitsch, M Bader… - …, 2024 - Am Heart Assoc
BACKGROUND: Angiotensin-(1-12), measured by a self-developed, polyclonal antibody-
based radioimmunoassay, has been suggested to act as an alternative precursor of …
based radioimmunoassay, has been suggested to act as an alternative precursor of …
Angiotensin-(1–9) in hypertension
I Norambuena-Soto, C Lopez-Crisosto… - Biochemical …, 2022 - Elsevier
Abstract Angiotensin-(1–9)[Ang-(1–9)] is a peptide of the non-canonical renin-angiotensin
system (RAS) synthesized from angiotensin I by the monopeptidase angiotensin-converting …
system (RAS) synthesized from angiotensin I by the monopeptidase angiotensin-converting …