Introduction: Oocyte quality and fertility decline with advanced maternal age. During
maturation within the ovarian follicle, the oocyte relies on the associated somatic cells …

Introduction: Oocytes and follicular somatic cells within the ovarian follicle are altered during
maturation and after exposure to culture in vitro. In the present study, we used a nontargeted …

Advanced maternal age is associated with a decline in fertility and oocyte quality. We used
novel metabolic microsensors to assess effects of mare age on single oocyte and embryo …

Background Maturation of oocytes under in vitro conditions (IVM) results in impaired
developmental competence compared to oocytes matured in vivo. As oocytes are closely …

Obesity is a growing concern in human and equine populations, predisposing to metabolic
pathologies and reproductive disturbances. Cellular lipid accumulation and mitochondrial …

Age-related changes in follicle paracrine signalling are not defined, and follicular gene
transcript abundance could predict oocyte viability. Granulosa cells from preovulatory …

Obesity is associated with disrupted reproductive cycles in mares, but the impact of obesity
on follicles and oocytes has received minimal attention. We investigated the impact of …

Well-controlled metabolism is the prerequisite for optimal oocyte development. To date,
numerous studies have focused mainly on the utilization of exogenous substrates by …

We hypothesised that advanced mare age is associated with follicle and oocyte gene
alterations. The aims of the study were to examine quantitative and temporal differences in …

Simple Summary Commercial in vitro embryo production in horses by ICSI (intracytoplasmic
sperm injection) is currently used to produce embryos clinically. However, the successful …