Chromatin is the complex of eukaryotic DNA and proteins required for the efficient
compaction of the nearly 2-meter-long human genome into a roughly 10-micron-diameter …

Histones are highly positively charged proteins that wrap our genome. Their surface
properties also make them prone to nonspecific interactions and aggregation. A class of …

Our genetic information is tightly packaged into a rather ingenious nucleoprotein complex
called chromatin in a manner that enables it to be rapidly accessed during genomic …

Histone proteins dynamically regulate chromatin structure and epigenetic signaling to
maintain cell homeostasis. These processes require controlled spatial and temporal …

In eukaryotes, DNA is organized into chromatin, a dynamic structure that enables DNA to be
accessed for processes such as transcription, replication and repair. To form, maintain or …

Histone chaperones can be broadly defined as histone-binding proteins that influence
chromatin dynamics in an ATP-independent manner. Their existence reflects the importance …

Nucleosomes represent the fundamental repeating unit of eukaryotic DNA, and comprise
eight core histones around which DNA is wrapped in nearly two superhelical turns. Histones …

In eukaryotes, DNA is organized into chromatin in a dynamic manner that enables it to be
accessed for processes such as transcription and repair. Histones, the chief protein …

The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

The functional organization of eukaryotic DNA into chromatin uses histones as components
of its building block, the nucleosome. Histone chaperones, which are proteins that escort …