The roles of Rev-erbα and circadian clock in colonic inflammation remain unclarified. Here
we show colon clock genes (including Rev-erbα) are dysregulated in mice with DSS …

We uncover a cycling and NF-κB–driven lncRNA (named Lnc-UC) that epigenetically
modifies transcription of circadian clock gene Rev-erb α, thereby linking circadian clock to …

Endogenous circadian clocks regulate 24-h rhythms of physiology and behavior. Circadian
rhythm disruption (CRD) is suggested as a risk factor for inflammatory bowel disease …

Disruption of the circadian rhythm is a contributory factor to clinical and pathophysiological
conditions, including cancer, the metabolic syndrome, and inflammation. Chronic and …

Background Tight crosstalk between the circadian and immune systems has been reported
in several inflammatory diseases. We hypothesized that circadian timekeeping was …

Circadian dysfunction is a common attribute of many neurodegenerative diseases, most of
which are associated with neuroinflammation. Circadian rhythm dysfunction has been …

Diurnal variation in inflammatory and immune function is evident in the physiology and
pathology of humans and animals, but molecular mechanisms and mediating cell types that …

The innate immune system senses “non-self” molecules derived from pathogens (PAMPs)
as well as endogenous damage-associated molecular patterns (DAMPs) and promotes …

Inflammatory bowel disease (IBD) comprises a group of chronic, immune system-mediated
inflammatory diseases that primarily affect the gastrointestinal tract. The pathogenesis of the …

Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are
associated with intestinal and systemic pathologies. Interactions between bacterial products …