It is well known that the presence of a blood–brain barrier (BBB) makes drug delivery to the
brain more challenging. There are various mechanistic routes through which therapeutic …

Brain is the most complex organ in human body. The prevalence of CNS diseases and their
associated secondary diseases has become the growing threat and huge disease burden to …

The treatment of central nervous system (CNS) disorders always remains a challenge for the
researchers. The presence of various physiological barriers, primarily the blood–brain …

The blood–brain barrier (BBB) has a pivotal role in maintaining brain homeostasis. It
robustly protects the brain parenchyma against the invasion of irrelevant substances, which …

The administration of drugs to the CNS has become a difficult task because several barriers
in the brain, ie the blood-brain barrier (BBB) and a blood-cerebrospinal fluid barrier must be …

The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …

The brain is a delicate organ, and nature has very efficiently protected it. Drug delivery into
the brain was difficult due to the existence of blood brain barrier, which only permits some …

Brain cancers and neurodegenerative diseases are on the rise, treatments for central
nervous system (CNS) diseases remain limited. Despite the significant advancement in drug …

One of the most challenging fields for pharmaceutical and biotechnological products is the
drug delivery to the central nervous system. According to the WHO records, 6.8 million …

The blood-brain barrier (BBB) is a neurobiological frontier that isolates brain tissues from the
blood vascular system. Its main role is to protect the brain and the central nervous system …