Despite recent advances in the treatment of human colon cancer, the chemotherapy efficacy
against colon cancer is still unsatisfactory. In the present study, effects of concomitant …

DNA methylation is an epigenetic phenomenon known to play an important role in the
development and progression of human cancer. Enzyme responsible for this process is DNA …

Background: Colorectal Cancer (CRC) is a common cause of oncological deaths worldwide.
Alterations of the epigenetic landscape constitute a well-documented hallmark of CRC …

Background Clinical trials of gefitinib (Iressa, ZD1839) in combination with cytotoxic agents
have been carried out or are ongoing in several varieties of tumor. To provide a rationale for …

Background DNA methylation is an epigenetic phenomenon known to play an important role
in the development of cancers, including colorectal cancer (CRC). Aberrant methylation of …

Gastric cancer is the fourth most common cancer type and the second leading cause of
cancer‑associated mortality worldwide. Metastasis is a crucial feature of its progression …

Here, we showed the antibiotic salinomycin (SAL) combined with GEF exerted synergistic
cytotoxicity effects in colorectal cancer cells irrespective of their EGFR and KRAS status, with …

Malignant growth and chemotherapy resistance to 5-fluorouracil (5-FU) are the obstacles to
the treatment of Colorectal cancer (CRC). There is need to develop effective therapeutic …

The sensitivity of lung cancer to epidermal growth factor receptor (EGFR)-tyrosine kinase
inhibitors (TKIs) has been found to be associated with mutations in the tyrosine kinase …

The hypomethylation agent decitabine (DAC), in combination with other apoptosis inducers,
is considered a potential modality for cancer treatment. We investigated the mechanism …