Few studies provide data on the global morbidity and mortality caused by infection with
Shigella spp.; such estimates are needed, however, to plan strategies of prevention and …

Despite a significant decrease in Shigella-related mortality, shigellosis continues to carry a
significant burden of disease worldwide, particularly in Asia and Africa. Shigella is a highly …

The global incidence of Shigella infection has been estimated at 80–165 million episodes
annually, with 99% of episodes occurring in the developing world. To identify contemporary …

The greatest barrier to the use of vaccine against shigellosis in developing areas is poor
immune responses to oral vaccines in children who have minimal maternal antibodies …

More than 50 years of research has yielded numerous Shigella vaccine candidates that
have exemplified both the promise of vaccine-induced prevention of shigellosis and the …

Almost all fatal cases of shigellosis occur in developing countries, and data on mortality are
generally compiled from three sources: investigations of epidemics caused by Shigella …

Abstract During 1989–2002, a total of 208,368 laboratory-confirmed Shigella infections were
reported to the Centers for Disease Control and Prevention. Shigella sonnei accounted for …

Shigellosis is an acute invasive enteric infection caused by bacteria belonging to the genus
Shigella; it is clinically manifested by diarrhoea that is frequently bloody. Shigellosis is …

Background The burden of shigellosis is greatest in resource-poor countries. Although this
diarrheal disease has been thought to cause considerable morbidity and mortality in excess …

In 1999, a review of the literature for 1966–1997 suggested that≈ 1.1 million persons die
annually of shigellosis, including≈ 880,000 in Asia. Our recent review of the literature for …