BACKGROUND: Establishing a chondrocyte model of osteoarthritis is of great significance
for further explaining the pathological process of osteoarthritis and evaluating and screening …

Objective To explore and identify the method for IL-1beta induced New Zealand rabbit knee
chondrocyte degeneration, thus providing experimental bases for Chinese medical research …

Abstract BACKGROUND: Bushen Huoxue Decoction has been found to be effective for
osteoarthritis and osteoporosis, but the underlying mechanisms are little reported …

Methods Chondrocytes were isolated from articular cartilages of newly born SD rats by
digestion with typeⅡ collagenase. The chondrocytes were cultured with H-DMEM medium …

Objective To evaluate the effect of interleukin-6 (IL-6) on the biological behaviors of the
chondrocytes in the cartilage endplate of rabbits. Methods Chondrocytes isolated from the …

BACKGROUND: Osteoarthritis is a kind of normal disease, results from a complex system of
interacting mechanical, biological, biochemical, molecular and enzymatic feedback loops …

BACKGROUND: Numerous studies addressing cells in osteoarthritis still focus on the in vitro
culture of articular chondrocytes in animal models. Degeneration in the animal models is not …

BACKGROUND: Most studies have shown that MAPK, nuclear factor κB, and Wnt signaling
pathways are the major signaling pathways associated with osteoarthritis. OBJECTIVE: To …

BACKGROUND: The inflammation of osteoarthritis is mediated by chondrocytes and the
synovial tissue-secreted cytokines. Articular cartilage and synovial tissue contains a variety …

Cytokines released at sites of inflammation and infection can alter the normal processes of
cartilage turnover, resulting in pathologic destruction or formation. Interleukin (IL)-1β plays a …