Cell penetrating peptides hold considerable potential for academic and pharmaceutical
remits with an interest in delivering macromolecules to the insides of cells. Hundreds of …

The permeability barrier imposed by cellular membranes limits the access of exogenous
compounds to the interior of cells. Researchers and patients alike would benefit from …

The selective permeability of the plasma membrane prohibits most exogenous agents from
gaining cellular access. Since many therapeutics and reporter molecules must be …

Cell-penetrating peptides (CPPs) are short peptides of less than 30 amino acids that are
able to penetrate cell membranes and translocate different cargoes into cells. The only …

The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability has made of delivery a keystone in therapeutic …

In this review, we discuss how cell-penetrating peptides (CPPs) might get access to their
intracellular targets. We specifically focus on the challenge of deciding whether the …

Cell penetrating peptides, generally categorized as amphipathic or cationic depending on
their sequence, are increasingly drawing attention as a non-invasive delivery technology for …

The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability have made of delivery a key stone in therapeutic …

The cell membrane poses a substantial hurdle to the use of pharmacologically active
biomacromolecules that are not per se actively translocated into cells. An appealing …

More than a decade ago, it was discovered that cationic peptides could traverse the cellular
plasma membrane without specific transporter proteins or membrane damage …