[PDF][PDF] Transcriptional landscape of human tissue lymphocytes unveils uniqueness of tumor-infiltrating T regulatory cells
M De Simone, A Arrigoni, G Rossetti, P Gruarin… - Immunity, 2016 - cell.com
Tumor-infiltrating regulatory T lymphocytes (Treg) can suppress effector T cells specific for
tumor antigens. Deeper molecular definitions of tumor-infiltrating-lymphocytes could thus …
tumor antigens. Deeper molecular definitions of tumor-infiltrating-lymphocytes could thus …
Unlocking the complexities of tumor-associated regulatory T cells
JL Chao, PA Savage - The Journal of Immunology, 2018 - journals.aai.org
Regulatory T (Treg) cells are found at elevated densities in many human cancers and are
thought to be a major barrier to the generation of robust antitumor T cell responses. In this …
thought to be a major barrier to the generation of robust antitumor T cell responses. In this …
[HTML][HTML] Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies
While regulatory T (Treg) cells are traditionally viewed as professional suppressors of
antigen presenting cells and effector T cells in both autoimmunity and cancer, recent …
antigen presenting cells and effector T cells in both autoimmunity and cancer, recent …
Regulation of regulatory T cells in cancer
The inflammatory response to transformed cells forms the cornerstone of natural or
therapeutically induced protective immunity to cancer. Regulatory T (Treg) cells are known …
therapeutically induced protective immunity to cancer. Regulatory T (Treg) cells are known …
Targeting regulatory T cells in tumors
C Liu, CJ Workman, DAA Vignali - The FEBS journal, 2016 - Wiley Online Library
Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and
preventing autoimmunity. However, they also represent a major barrier to effective antitumor …
preventing autoimmunity. However, they also represent a major barrier to effective antitumor …
Regulatory T‐cell development in the tumor microenvironment
K Itahashi, T Irie, H Nishikawa - European journal of …, 2022 - Wiley Online Library
Regulatory T (Treg) cells are required for maintaining self‐tolerance and preventing the
development of autoimmune diseases. However, Treg cells are abundant in tumors and …
development of autoimmune diseases. However, Treg cells are abundant in tumors and …
Regulatory T cells in cancer
G Plitas, AY Rudensky - Annual Review of Cancer Biology, 2020 - annualreviews.org
The immune system has evolved complex effector mechanisms to protect the host against a
diversity of pathogenic organisms and regulatory adaptations that can curtail pathological …
diversity of pathogenic organisms and regulatory adaptations that can curtail pathological …
Therapeutic targeting of regulatory T cells in cancer
F Shan, A Somasundaram, TC Bruno, CJ Workman… - Trends in cancer, 2022 - cell.com
The success of immunotherapy in oncology underscores the vital role of the immune system
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …
in cancer development. Regulatory T cells (Tregs) maintain a fine balance between …
[HTML][HTML] Exhaust the exhausters: Targeting regulatory T cells in the tumor microenvironment
BR McRitchie, B Akkaya - Frontiers in immunology, 2022 - frontiersin.org
The concept of cancer immunotherapy has gained immense momentum over the recent
years. The advancements in checkpoint blockade have led to a notable progress in treating …
years. The advancements in checkpoint blockade have led to a notable progress in treating …
Intratumoral regulatory T cells: markers, subsets and their impact on anti‐tumor immunity
H Yano, LP Andrews, CJ Workman, DAA Vignali - Immunology, 2019 - Wiley Online Library
Regulatory T (Treg) cells play a crucial role in maintaining self‐tolerance and resolution of
immune responses by employing multifaceted immunoregulatory mechanisms. However …
immune responses by employing multifaceted immunoregulatory mechanisms. However …