A major obstacle to understanding the functional importance of dimerization between class
AG protein–coupled receptors (GPCRs) has been the methodological limitation in achieving …

Here we present a new method that combines protein complementation with resonance
energy transfer to study conformational changes in response to activation of a defined G …

G protein-coupled receptors (GPCRs), G proteins and adenylyl cyclase (AC) comprise one
of the most studied transmembrane cell signaling pathways. However, it is unknown whether …

G protein-coupled receptor (GPCR) heteromers are macromolecular complexes with unique
functional properties different from those of its individual protomers. Little is known about …

G protein–coupled receptors (GPCRs) are intensely studied as drug targets and for their role
in signaling. With the determination of the first crystal structures, interest in structure-based …

The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell
membrane and allosteric interactions across the A2AR–D2R heteromer represent a target …

The quaternary structure of G protein-coupled receptors (GPCRs) can influence their
trafficking and ability to transduce signals. GPCR oligomers are generally portrayed as long …

Evidence that class AG protein-coupled receptors (GPCRs) can assemble as dimers or
higher-order oligomers has steadily accumulated for two decades. However, the structural …

The opioid system modulates several physiological processes, including analgesia, the
stress response, the immune response and neuroendocrine function. Pharmacological and …

Class A G-protein-coupled receptors (GPCRs) are a large family of membrane proteins that
mediate a wide variety of physiological functions, including vision, neurotransmission and …