DNA methylation is a fundamental epigenetic mechanism that is involved in long-term
programming of gene expression and in determining cell fate by regulating cell-specific …

Epigenetic alterations have been implicated in the development and progression of human
cancer. It is noteworthy that epigenetic modifications, in contrast to genetic mutations, are …

Epigenetics refers to partially reversible, somatically inheritable, but DNA sequence-
independent traits that modulate gene expression, chromatin structure, and cell functions …

DNA methylation is an epigenetic modification that contributes to essential biological
processes such as retrotransposon silencing, cell differentiation, genomic imprinting and X …

Background DNA methylation is the addition of a methyl group to the 5 position of cytosine. It
is an epigenetic process with several effects, including chromatin structure modulation …

DNA methylation is a critical component of gene regulation and plays an important role in
the development of cancer. Hypermethylation of tumor suppressor genes and silencing of …

DNA methylation is a major epigenetic mechanism that leads to inhibition of gene
transcription and is known to be involved in the pathogenesis of cancer. The effectors of …

The most extensively studied inhibitors of DNA methylation are the cytidine analogs 5-
azacytidine (5-aza-CR; azacitidine) and 5-aza-2′-deoxycytidine (5-aza-CdR; decitabine) …

Targeting DNA methylation for cancer therapy has had a rocky history. The first reports on
DNA methylation changes in cancer described global loss of methylation, which has been …

DNA methylation is an epigenetic modification involved in gene expression regulation. In
cancer, the DNA methylation pattern becomes aberrant, causing an array of tumor …