The cleavage of tetramer ACAγ T was carried out using two deblocking protocols:(I) the
standard 'lowhigh TfOH'treat ment of resin with solution of 'low TfOH'–TFA/mcresol/DMS …

Effective preparative synthesis of two thymine containing monomers of polyamide DNA-
mimics based on L-alanine and glycine is presented. The results of investigation are more …

S-Thyminyl-L-cysteine methyl ester hydrochloride (compound 1), a non-classical peptide
nucleic acid monomer, was synthesized through the key intermediate, N-tert-butoxycarbonyl …

Peptide nucleic acids (PNAs) make a promising group of DNA analogues. The backbone of
typical PNA oligomers is composed of N-(2-aminoethyl) glycine units, linked by the peptide …

BOYARSKAYA et al. yields, respectively, by the Mitsunobu condensation [7] of amino
alcohols 6 and 7 with the o-NBS glycine derivative under conditions described previously [6] …

This paper considers the site-directed cleavage of the in vitro transcript of human tRNA Lys 3
by the conjugate C NH 2 Gly (ArgLeu) 3 ArgLeu N—p-DAG—5" CCCTGGACCCTCAGAT …

RNA cleaving conjugates have been prepared by attachment of oligodeoxyribonucleotide
TTTT to peptides containing arginine, leucine, proline and serine residues. The highest …

Homopyrimidine polyamide nucleic acid mimics based on L-glutamic acid were prepared by
solid-phase synthesis. The effect of the conditions of condensation and cleavage reactions …

“Peptide nucleic acid”(PNA) oligomers replace the oligonucleotide backbone of DNA with an
achiral and neutral poly [N-(2-aminoethyl) glycine] backbone, and the four natural …

The synthesis of thymine-containing monomers of negatively charged peptide nucleic acids
from L-glutamic acid derivatives is described. Two approaches to the pseudopeptide …