Tuberculosis IRIS: pathogenesis, presentation, and management across the spectrum of disease

CM Quinn, V Poplin, J Kasibante, K Yuquimpo… - Life, 2020 - mdpi.com
Antiretroviral therapy (ART), while essential in combatting tuberculosis (TB) and HIV
coinfection, is often complicated by the TB-associated immune reconstitution inflammatory …

The immunopathogenesis of the HIV tuberculosis immune reconstitution inflammatory syndrome

RPJ Lai, JK Nakiwala, G Meintjes… - European journal of …, 2013 - Wiley Online Library
HIV‐1 patients co‐infected with some pathogens are at risk of developing the immune
reconstitution inflammatory syndrome (IRIS) when initiating antiretroviral therapy (ART). IRIS …

[HTML][HTML] TB-IRIS pathogenesis and new strategies for intervention: Insights from related inflammatory disorders

PM Cevaal, LG Bekker, S Hermans - Tuberculosis, 2019 - Elsevier
In almost one in five HIV/tuberculosis (TB) co-infected patients, initiation of antiretroviral
therapy (ART) is complicated by TB immune reconstitution inflammatory syndrome (TB-IRIS) …

Tuberculosis-immune reconstitution inflammatory syndrome in HIV: from pathogenesis to prediction

N Gopalan, BB Andrade… - Expert review of clinical …, 2014 - Taylor & Francis
Tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) is an exaggerated,
dysregulated immune response against dead or viable antigens of Mycobacterium …

[HTML][HTML] Cytotoxic mediators in paradoxical HIV–tuberculosis immune reconstitution inflammatory syndrome

KA Wilkinson, NF Walker, G Meintjes… - The Journal of …, 2015 - journals.aai.org
Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) frequently
complicates combined antiretroviral therapy and antituberculosis therapy in HIV-1 …

The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome

HTT Tran, R Van den Bergh, TN Vu, K Laukens… - Immunobiology, 2014 - Elsevier
Abstract Background Tuberculosis-associated Immune Reconstitution Inflammatory
Syndrome (TB-IRIS) is a common complication of combined antiretroviral therapy (cART) in …

Clinical spectrum, risk factors and outcome of immune reconstitution inflammatory syndrome in patients with tuberculosis–HIV coinfection

W Worodria, J Menten, M Massinga-Loembe… - Antiviral …, 2012 - journals.sagepub.com
Background Here, we aimed to determine the clinical spectrum, predictors and outcomes of
paradoxical tuberculosis-immune reconstitution inflammatory syndrome (TB-IRIS) in a …

Paradoxical TB-IRIS in HIV-infected adults: a systematic review and meta-analysis

PE Namale, LH Abdullahi, S Fine… - Future …, 2015 - Taylor & Francis
Paradoxical tuberculosis immune reconstitution inflammatory syndrome (TB-IRIS) was first
described almost two decades ago. We undertook this systematic review and meta-analysis …

Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+ T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated …

S Ravimohan, N Tamuhla, K Nfanyana… - Clinical Infectious …, 2016 - academic.oup.com
Background. The immunopathogenesis of paradoxical tuberculosis-associated immune
reconstitution inflammatory syndrome (TB-IRIS) remains unclear. We determined the …

Tuberculosis immune reconstitution inflammatory syndrome in A5221 STRIDE: timing, severity, and implications for HIV–TB programs

AF Luetkemeyer, MA Kendall, M Nyirenda… - JAIDS Journal of …, 2014 - journals.lww.com
Rationale and Objectives: Earlier initiation of antiretroviral therapy (ART) in HIV–tuberculosis
(TB) is associated with increased immune reconstitution inflammatory syndrome (IRIS). The …