Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by β-amyloid peptides via p38 mitogen-activated protein kinase pathway
PM Canas, LO Porciúncula, GMA Cunha… - Journal of …, 2009 - Soc Neuroscience
Alzheimer's disease (AD) is characterized by memory impairment, neurochemically by
accumulation of β-amyloid peptide (namely Aβ1-42) and morphologically by an initial loss of …
accumulation of β-amyloid peptide (namely Aβ1-42) and morphologically by an initial loss of …
Caffeine and adenosine A2a receptor antagonists prevent β-amyloid (25–35)-induced cognitive deficits in mice
OP Dall'Igna, P Fett, MW Gomes, DO Souza… - Experimental …, 2007 - Elsevier
Consumption of caffeine, an adenosine receptor antagonist, was found to be inversely
associated with the incidence of Alzheimer's disease. Moreover, caffeine protects cultured …
associated with the incidence of Alzheimer's disease. Moreover, caffeine protects cultured …
Astrocytic adenosine A 2A receptors control the amyloid-β peptide-induced decrease of glutamate uptake
Alzheimer's disease (AD) is characterized by a progressive cognitive impairment tightly
correlated with the accumulation of amyloid-β (Aβ) peptides (mainly Aβ 1-42). There is a …
correlated with the accumulation of amyloid-β (Aβ) peptides (mainly Aβ 1-42). There is a …
Adenosine A2A receptor blockade prevents memory dysfunction caused by β-amyloid peptides but not by scopolamine or MK-801
GMA Cunha, PM Canas, CS Melo, J Hockemeyer… - Experimental …, 2008 - Elsevier
Adenosine A2A receptor antagonists alleviate memory deficits caused by aging or by
administration of β-amyloid peptides in rodents, which is in accordance with the beneficial …
administration of β-amyloid peptides in rodents, which is in accordance with the beneficial …
Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease
E Faivre, JE Coelho, K Zornbach, E Malik… - Frontiers in molecular …, 2018 - frontiersin.org
Consumption of caffeine, a non-selective adenosine A2A receptor (A2AR) antagonist,
reduces the risk of developing Alzheimer's disease (AD) and mitigates both amyloid and Tau …
reduces the risk of developing Alzheimer's disease (AD) and mitigates both amyloid and Tau …
Neuroprotection by caffeine and adenosine A2A receptor blockade of β‐amyloid neurotoxicity
OP Dall'lgna, LO Porciúncula, DO Souza… - British journal of …, 2003 - Wiley Online Library
Adenosine is a neuromodulator in the nervous system and it has recently been observed
that pharmacological blockade or gene disruption of adenosine A2A receptors confers …
that pharmacological blockade or gene disruption of adenosine A2A receptors confers …
Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline
RA Cunha, PM Agostinho - Journal of Alzheimer's Disease, 2010 - content.iospress.com
Caffeine, the most widely consumed psychoactive drug, enhances attention/vigilance,
stabilizes mood, and might also independently enhance cognitive performance. Notably …
stabilizes mood, and might also independently enhance cognitive performance. Notably …
The role of adenosine in Alzheimer's disease
A Rahman - Current neuropharmacology, 2009 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system
manifested by cognitive and memory deterioration, a variety of neuropsychiatric symptoms …
manifested by cognitive and memory deterioration, a variety of neuropsychiatric symptoms …
A2A adenosine receptor deletion is protective in a mouse model of Tauopathy
C Laurent, S Burnouf, B Ferry, VL Batalha… - Molecular …, 2016 - nature.com
Consumption of caffeine, a non-selective adenosine A 2A receptor (A 2A R) antagonist,
reduces the risk of developing Alzheimer's disease (AD) in humans and mitigates both …
reduces the risk of developing Alzheimer's disease (AD) in humans and mitigates both …
[HTML][HTML] Synaptic and memory dysfunction in a β-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine
FQ Gonçalves, JP Lopes, HB Silva, C Lemos… - Neurobiology of …, 2019 - Elsevier
Abstract Adenosine A 2A receptors (A 2A R) overfunction causes synaptic and memory
dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ 1-42)-based model of early …
dysfunction in early Alzheimer's disease (AD). In a β-amyloid (Aβ 1-42)-based model of early …