Cerebrovascular disease is the most common life-threatening and debilitating condition that
often leads to stroke. The multifunctional calcium/calmodulin-dependent protein kinase II …

Background and Purpose—Elevation of intracellular calcium was traditionally thought to be
detrimental in stroke pathology. However, clinical trials testing treatments that block calcium …

First characterized in neuronal tissues, the multifunctional calcium/calmodulin-dependent
protein kinase II (CaMKII) is a key signaling component in several mammalian biological …

Abstract Ca 2+/calmodulin-dependent protein kinase II (CaMKII) has long been implicated in
neuronal injury caused by acute ischemia/reperfusion (I/R). However, its precise role and …

Ischemic insults on neurons trigger excessive, pathological glutamate release that causes
Ca 2+ overload resulting in neuronal cell death (excitotoxicity). The Ca 2+/calmodulin (CaM) …

Brain microvascular endothelial cells play an essential role in maintaining blood–brain
barrier (BBB) integrity, and disruption of the BBB aggravates the ischemic injury. Ca MKK (α …

Ca 2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) is a major mediator of
physiological glutamate signaling involved in higher brain functions. Here, we show CaMKII …

CaMKII (calcium/calmodulin-stimulated protein kinase II) is a multifunctional protein kinase
that regulates normal neuronal function. CaMKII is regulated by multi-site phosphorylation …

The calcium/calmodulin-dependent protein kinase II (CaMKII) is a ubiquitous and central
player in Ca2+ signaling that is best known for its functions in the brain. In particular, the α …

Different brain regions exhibit differing sensitivities to ischemia/excitotoxicity. Whether these
differences are due to perfusion or intrinsic factors has not been established. Herein, we …