Directional differentiation of stem cells is a key step in stem cell therapy. In this study, we
developed saponin-based nanoparticles (Ad-SNPs) containing dexamethasone (Dex) and …

Current nanostructured biomaterials-based drug delivery vehicles for bone regeneration
applications often show suboptimal cellular uptake and inferior drug loading. To overcome …

Bone morphogenetic protein-2 (BMP-2), a growth factor that induces osteoblast
differentiation and promotes bone regeneration, has been extensively investigated in bone …

To achieve enhanced stimulatory effects on the osteogenic differentiation of stem cells, the
combination of dual factors with synergistic bioactivity has been regarded as the most …

Stem cells are well-known for their great capacity for tissue regeneration. This provides a
promising source for cell-based therapies in treating various bone degenerative disorders …

Potentiation of stem cell potency is critical for successful tissue engineering, especially for
bone regeneration. Three-dimensional cell culture and bioactive molecule co-delivery with …

Background Stromal cell-derived factor 1 (SDF-1) is an important chemokine for stem cell
mobilization, and plays a critical role in mobilization of mesenchymal stem cells (MSCs) …

Bone regeneration requires the presence of specific factors to induce the differentiation of
stem cells into osteoblasts. These factors induce osteogenesis by stimulating the expression …

Mimicking hybrid extracellular matrix is one of the major challenges in bone tissue
engineering. Biocomposite micro/nanoparticle of polycaprolactone (PCL), silk fibroin (SF) …

Introduction The repair of bone defects is ideally accomplished with bone tissue
engineering. Recent studies have explored the possibility of functional modification of …