Bacteriophages inhibit and evade cGAS-like immune function in bacteria
E Huiting, X Cao, J Ren, JS Athukoralage, Z Luo… - Cell, 2023 - cell.com
A fundamental strategy of eukaryotic antiviral immunity involves the cGAS enzyme, which
synthesizes 2′, 3′-cGAMP and activates the effector STING. Diverse bacteria contain …
synthesizes 2′, 3′-cGAMP and activates the effector STING. Diverse bacteria contain …
Bacterial cGAS senses a viral RNA to initiate immunity
Cyclic oligonucleotide-based antiphage signalling systems (CBASS) protect prokaryotes
from viral (phage) attack through the production of cyclic oligonucleotides, which activate …
from viral (phage) attack through the production of cyclic oligonucleotides, which activate …
[HTML][HTML] Cyclic GMP–AMP signalling protects bacteria against viral infection
The cyclic GMP–AMP synthase (cGAS)–STING pathway is a central component of the cell-
autonomous innate immune system in animals,. The cGAS protein is a sensor of cytosolic …
autonomous innate immune system in animals,. The cGAS protein is a sensor of cytosolic …
[HTML][HTML] CBASS phage defense and evolution of antiviral nucleotide signaling
B Duncan-Lowey, PJ Kranzusch - Current opinion in immunology, 2022 - Elsevier
Cyclic oligonucleotide-based antiphage signaling system (CBASS) immunity is a
widespread form of antiphage defense in bacteria and archaea. Each CBASS operon …
widespread form of antiphage defense in bacteria and archaea. Each CBASS operon …
CBASS to cGAS-STING: the origins and mechanisms of nucleotide second messenger immune signaling
KM Slavik, PJ Kranzusch - Annual Review of Virology, 2023 - annualreviews.org
Host defense against viral pathogens is an essential function for all living organisms. In cell-
intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of …
intrinsic innate immunity, dedicated sensor proteins recognize molecular signatures of …
Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence
Abstract cGAS is an evolutionarily conserved enzyme that has a pivotal role in immune
defence against infection,–. In vertebrate animals, cGAS is activated by DNA to produce …
defence against infection,–. In vertebrate animals, cGAS is activated by DNA to produce …
cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans
The metazoan cGAMP-activated cGAS–STING innate immunity pathway is triggered in
response to genomic instability and DNA damage, thereby providing host defense against …
response to genomic instability and DNA damage, thereby providing host defense against …
Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems
Cyclic-oligonucleotide-based anti-phage signalling systems (CBASS) are a family of
defence systems against bacteriophages (hereafter phages) that share ancestry with the …
defence systems against bacteriophages (hereafter phages) that share ancestry with the …
Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′, 2′-cGAMP as the second messenger
Cyclic-oligonucleotide-based antiphage signaling systems (CBASS) are diverse and
abundant in bacteria. Here, we present the biochemical and structural characterization of …
abundant in bacteria. Here, we present the biochemical and structural characterization of …
Evolutionary origins of cGAS-STING signaling
SR Margolis, SC Wilson, RE Vance - Trends in immunology, 2017 - cell.com
Detection of foreign nucleic acids is an important strategy for innate immune recognition of
pathogens. In vertebrates, pathogen-derived DNA is sensed in the cytosol by cGAS, which …
pathogens. In vertebrates, pathogen-derived DNA is sensed in the cytosol by cGAS, which …