Elevated prohibitin 1 expression mitigates glucose metabolism defects in granulosa cells of infertile patients with endometriosis

J Mao, J Zhang, L Cai, Y Cui, J Liu… - Molecular Human …, 2022 - academic.oup.com
Endometriosis is a common disease in women of childbearing age and is closely associated
with female infertility. However, the pathogenesis of endometriosis-related infertility is still …

Knockdown of prohibitin expression promotes glucose metabolism in eutopic endometrial stromal cells from women with endometriosis

X Qi, Y Zhang, H Ji, X Wu, F Wang, M Xie, L Shu… - Reproductive …, 2014 - Elsevier
In this in-vitro study, the effect of prohibitin (PHB) on glucose metabolism in eutopic
endometrial stromal cells from women with endometriosis was investigated. Endometrial …

Prohibitin2/PHB2, transcriptionally regulated by GABPA, inhibits cell growth via PRKN/Parkin-dependent mitophagy in endometriosis

Y Deng, T Lou, L Kong, C Liu - Reproductive Sciences, 2023 - Springer
Endometriosis (EMS) is a common benign gynecological disease affecting women of
reproductive age. It is characterized by abnormal growth of endometrial tissue outside the …

Prohibitin (PHB) roles in granulosa cell physiology

I Chowdhury, K Thomas, WE Thompson - Cell and tissue research, 2016 - Springer
Ovarian granulosa cells (GC) play an important role in the growth and development of the
follicle in the process known as folliculogenesis. In the present review, we focus on recent …

Characterization of prohibitin in a newly established rat ovarian granulosa cell line

WE Thompson, A Branch, JA Whittaker, D Lyn… - …, 2001 - academic.oup.com
Prohibitin is an evolutionary conserved protein that is associated with cellular differentiation,
atresia, and luteolysis in the rat ovary. However, the specific cellular location and function of …

Follicular stage-dependent regulation of apoptosis and steroidogenesis by prohibitin in rat granulosa cells

Q Wang, A Leader, BK Tsang - Journal of ovarian research, 2013 - Springer
Background Follicular growth and atresia are tightly regulated processes, which involve the
participation of endocrine, autocrine and paracrine factors at the cellular level. Prohibitin …

Prohibitin (PHB) interacts with AKT in mitochondria to coordinately modulate sperm motility

XH Li, RR Chai, GW Chen, LF Zhang… - Asian Journal of …, 2020 - journals.lww.com
Prohibitin (PHB), an evolutionarily conserved mitochondrial inner membrane protein, is
highly expressed in cells that require strong mitochondrial function. Recently, we …

Apoptosis of rat granulosa cells after staurosporine and serum withdrawal is suppressed by adenovirus-directed overexpression of prohibitin

I Chowdhury, W Xu, JK Stiles, A Zeleznik, X Yao… - …, 2007 - academic.oup.com
Prohibitin (Phb1) is a highly conserved mitochondrial protein that is associated with
granulosa cell differentiation, atresia, and luteolysis. Although prohibitin has been implicated …

[HTML][HTML] Prohibitin regulates the FSH signaling pathway in rat granulosa cell differentiation

I Chowdhury, K Thomas, A Zeleznik… - Journal of Molecular …, 2016 - ncbi.nlm.nih.gov
Published results from our laboratory identified prohibitin (PHB), a gene product expressed
in granulosa cells (GCs) that progressively increases during follicle maturation. Our current …

Gonadotropin-releasing hormone-regulated prohibitin mediates apoptosis of the gonadotrope cells

D Savulescu, J Feng, YS Ping, O Mai… - Molecular …, 2013 - academic.oup.com
GnRH regulates circulating levels of the gonadotropins but has also been implicated in
establishing the gonadotrope cell population. Consistent with this, GnRH induces …