Localization of memory CD8+ T cells to lymphoid or peripheral tissues is believed to
correlate with proliferative capacity or effector function. Here we demonstrate that the …

Immunosenescence, or ageing of the immune system, contributes to the increased morbidity
and mortality seen in the elderly population. Premature immunosenescence is shown to …

Strength of inflammatory stimuli during the early expansion phase plays a crucial role in the
effector versus memory cell fate decision of CD8+ T cells. But it is not known how early …

Background Adoptive T-cell based immunotherapies constitute a promising approach to
treat cancer, however, a major problem is to obtain effective and long-lasting anti-tumor …

T cells dynamically interact with multiple, distinct cellular subsets to determine effector and
memory differentiation. Here, we developed a platform to quantify cell location in three …

The mechanisms underlying the heightened protection mediated by central memory CD8+ T
(TCM) cells remain unclear. Here we show that the transcription factor Tcf1 was required in …

Generation of a robust immunological memory response is essential for protection on
subsequent encounters with the same pathogen. The magnitude and quality of the memory …

Tissue-resident memory T (T RM) cells serve as vanguards of antimicrobial host defense in
nonlymphoid tissues, particularly at barrier epithelia and in organs with nonrenewable cell …

Antigen-driven T cell education and subsequent pathogen elimination present particular
challenges for the immune system. Pathogens generally enter the body at peripheral sites …

A fundamental benefit of immunological memory is the ability to respond in an enhanced
manner upon secondary encounter with the same pathogen. Tissue-resident memory CD8 T …